ID   WCWK3_STREE             Reviewed;         329 AA.
AC   Q4K0S9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Capsular polysaccharide phosphotransferase WcwK;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein WcwK;
GN   Name=wcwK; ORFNames=SPC20_0013;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=34365 / Serotype 20;
RX   PubMed=16532061; DOI=10.1371/journal.pgen.0020031;
RA   Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA   Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA   Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA   Spratt B.G.;
RT   "Genetic analysis of the capsular biosynthetic locus from all 90
RT   pneumococcal serotypes.";
RL   PLoS Genet. 2:262-268(2006).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; CR931679; CAI33721.1; -; Genomic_DNA.
DR   RefSeq; WP_000247840.1; NZ_UHGO01000005.1.
DR   AlphaFoldDB; Q4K0S9; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..329
FT                   /note="Capsular polysaccharide phosphotransferase WcwK"
FT                   /id="PRO_0000235969"
SQ   SEQUENCE   329 AA;  39631 MW;  C9B870A33141208B CRC64;
     MVNNIDFVVT WVNGNDPVWR EEKKKYEVLD GRPTLNDETR YRDMDLFQYW FRAVEKHAPW
     VNNIYFITYG HLPEWLDANH PKLKIVKHED YIPKEYLPTF SSNVIELNLF RIKELSEQFV
     LFSDDVFINT FLKEEDLFKN NLPRLLSIYR PLIPTKEFDY INFNHLLIMN RYFHDKKTLS
     QHKGKFFNVG YGKFNLYNLF SIFYSGIIGY HDAHVAMPHL KSTFAEIWNK EGVLLDRVCK
     NKFRSTKDVN HWLMSYWNIE TNSFMPQTLR VGEYVPLAYS GKIESIIHKQ KNKFLCINDD
     EHTENFINEV NFVRKIFEKK FPEKSKFEK