ID   WCWK5_STREE             Reviewed;         335 AA.
AC   Q4K2U1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Capsular polysaccharide phosphotransferase WcwK;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein WcwK;
GN   Name=wcwK; ORFNames=SPC07B_0012;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Johnson / Serotype 7B;
RX   PubMed=16532061; DOI=10.1371/journal.pgen.0020031;
RA   Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA   Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA   Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA   Spratt B.G.;
RT   "Genetic analysis of the capsular biosynthetic locus from all 90
RT   pneumococcal serotypes.";
RL   PLoS Genet. 2:262-268(2006).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; CR931641; CAI32887.1; -; Genomic_DNA.
DR   RefSeq; WP_050079279.1; NZ_UHHG01000005.1.
DR   AlphaFoldDB; Q4K2U1; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR021520; Stealth_CR2.
DR   Pfam; PF11380; Stealth_CR2; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..335
FT                   /note="Capsular polysaccharide phosphotransferase WcwK"
FT                   /id="PRO_0000235971"
SQ   SEQUENCE   335 AA;  40311 MW;  3D0728E1E0B87B44 CRC64;
     MKNMEQIDFV VTWVNDKDVD WCKRKSEFEK EYNIFQDLNS EERYREWGLM KYWFRAVEKY
     APWVNKIYFI TEGHVPNWLD VNHPKLVHVK HEDYIEKQFL PTFNSNVIEM NLIHLKDLSE
     KFVLFNDDFF INDFVKQSDF FENNLPKDTG IFSPLIPREN SLTPIILNNM EIINKYFSKK
     KILEQNFSKF FNIKYGKHLL KNICLLPWSD LLGFYDNHIP VSYCKSNFLE VYEKEHAIFN
     LTFKNKFRNK NEINHWLIRY WQLSSGNFIP RNINFGKNYA ISNDPTDIIN ELKLSKYKII
     CINDGESIDN FDAVKGLMIN AFEKKFPEKS SFEKK