ID   WD82A_XENLA             Reviewed;         313 AA.
AC   Q640J6;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=WD repeat-containing protein 82-A {ECO:0000305};
GN   Name=wdr82-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory component of the SET1 complex implicated in the
CC       tethering of this complex to transcriptional start sites of active
CC       genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via
CC       recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-
CC       terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part
CC       of a transcription termination checkpoint that promotes transcription
CC       termination of long non-coding RNAs (lncRNAs).
CC       {ECO:0000250|UniProtKB:Q6UXN9}.
CC   -!- SUBUNIT: Component of the SET1 complex. {ECO:0000250|UniProtKB:Q6UXN9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6UXN9}.
CC       Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with
CC       chromatin (By similarity). Recruited at sites of high RNA polymerase II
CC       occupancy (By similarity). {ECO:0000250|UniProtKB:Q6UXN9,
CC       ECO:0000250|UniProtKB:Q8BFQ4}.
CC   -!- SIMILARITY: Belongs to the WD repeat SWD2 family. {ECO:0000305}.
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DR   EMBL; BC082629; AAH82629.1; -; mRNA.
DR   RefSeq; NP_001087972.1; NM_001094503.1.
DR   RefSeq; XP_018112333.1; XM_018256844.1.
DR   AlphaFoldDB; Q640J6; -.
DR   SMR; Q640J6; -.
DR   BioGRID; 104737; 1.
DR   IntAct; Q640J6; 1.
DR   DNASU; 494657; -.
DR   GeneID; 494657; -.
DR   KEGG; xla:494657; -.
DR   CTD; 494657; -.
DR   Xenbase; XB-GENE-6255612; wdr82.L.
DR   OMA; MAFRDYN; -.
DR   OrthoDB; 1146727at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 494657; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0110064; P:lncRNA catabolic process; ISS:UniProtKB.
DR   GO; GO:0032785; P:negative regulation of DNA-templated transcription, elongation; ISS:UniProtKB.
DR   GO; GO:0140744; P:negative regulation of lncRNA transcription; ISS:UniProtKB.
DR   GO; GO:0071027; P:nuclear RNA surveillance; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037867; Swd2/WDR82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19861; PTHR19861; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Transcription termination; WD repeat.
FT   CHAIN           1..313
FT                   /note="WD repeat-containing protein 82-A"
FT                   /id="PRO_0000279689"
FT   REPEAT          19..58
FT                   /note="WD 1"
FT   REPEAT          105..144
FT                   /note="WD 2"
FT   REPEAT          146..184
FT                   /note="WD 3"
FT   REPEAT          192..231
FT                   /note="WD 4"
FT   REPEAT          236..276
FT                   /note="WD 5"
FT   REPEAT          280..313
FT                   /note="WD 6"
SQ   SEQUENCE   313 AA;  35147 MW;  A36C18347926E916 CRC64;
     MKLTDGVLRS FRVAKVFREN SDKINCFDFS PTGETVISSS DDDSIVLYDC QEGKPKRTLY
     SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHSKRV VALSMSPVDD
     TFISASLDKT IRLWDLRSPN CQGLMHLQGK PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD
     KGPFATFKMQ YDRTCEWTSL KFSQDGKLIL MSTNGGFLRL VDAFKGAVMH TFGGYNNSKA
     VTLEASFTPD SQFIMIGSED GKIHVWNCES GMKVAVLDGK HTGPITCLQF NPKFMTFASA
     CSNMAFWLPT IDD