WDCP_HUMAN
ID WDCP_HUMAN Reviewed; 721 AA.
AC Q9H6R7; D6W532; Q8IYK0; Q9HBP5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=WD repeat and coiled-coil-containing protein {ECO:0000305};
GN Name=WDCP {ECO:0000312|HGNC:HGNC:26157}; Synonyms=C2orf44; ORFNames=PP384;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HCK, AND MUTAGENESIS OF
RP PRO-540 AND PRO-543.
RX PubMed=25469238; DOI=10.3892/br.2014.374;
RA Yokoyama N., Miller W.T.;
RT "Molecular characterization of WDCP, a novel fusion partner for the
RT anaplastic lymphoma tyrosine kinase ALK.";
RL Biomed. Rep. 3:9-13(2015).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH HCK, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=12029088; DOI=10.1074/jbc.m202783200;
RA Scott M.P., Zappacosta F., Kim E.Y., Annan R.S., Miller W.T.;
RT "Identification of novel SH3 domain ligands for the Src family kinase Hck.
RT Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP),
RT and ELMO1.";
RL J. Biol. Chem. 277:28238-28246(2002).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299; SER-501 AND SER-523, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-690, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-690, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [13]
RP CHROMOSOMAL TRANSLOCATION WITH ALK.
RX PubMed=22327622; DOI=10.1038/nm.2673;
RA Lipson D., Capelletti M., Yelensky R., Otto G., Parker A., Jarosz M.,
RA Curran J.A., Balasubramanian S., Bloom T., Brennan K.W., Donahue A.,
RA Downing S.R., Frampton G.M., Garcia L., Juhn F., Mitchell K.C., White E.,
RA White J., Zwirko Z., Peretz T., Nechushtan H., Soussan-Gutman L., Kim J.,
RA Sasaki H., Kim H.R., Park S.I., Ercan D., Sheehan C.E., Ross J.S.,
RA Cronin M.T., Jaenne P.A., Stephens P.J.;
RT "Identification of new ALK and RET gene fusions from colorectal and lung
RT cancer biopsies.";
RL Nat. Med. 18:382-384(2012).
RN [14]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299; SER-468; THR-530;
RP SER-686 AND SER-690, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [16]
RP VARIANT [LARGE SCALE ANALYSIS] SER-454.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SUBUNIT: Oligomer. Interacts with HCK (via SH3 domain).
CC {ECO:0000269|PubMed:12029088, ECO:0000269|PubMed:25469238}.
CC -!- INTERACTION:
CC Q9H6R7-2; P23560-2: BDNF; NbExp=3; IntAct=EBI-25833271, EBI-12275524;
CC Q9H6R7-2; P07900: HSP90AA1; NbExp=3; IntAct=EBI-25833271, EBI-296047;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H6R7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6R7-2; Sequence=VSP_027713, VSP_027714;
CC Name=3;
CC IsoId=Q9H6R7-3; Sequence=VSP_027712, VSP_027715;
CC -!- PTM: Phosphorylated on Tyr when associated with HCK.
CC {ECO:0000269|PubMed:25469238}.
CC -!- DISEASE: Note=A chromosomal aberration involving WDCP is found in one
CC subject with colorectal cancer. Translocation t(2;2)(p23.3;p23.1). A 5
CC million base pair tandem duplication generates an in-frame WDCP-ALK
CC gene fusion. {ECO:0000269|PubMed:22327622}.
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DR EMBL; AF218013; AAG17255.1; -; mRNA.
DR EMBL; AK025598; BAB15186.1; -; mRNA.
DR EMBL; AC104665; AAY24115.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00771.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00772.1; -; Genomic_DNA.
DR EMBL; BC035698; AAH35698.1; -; mRNA.
DR CCDS; CCDS1705.1; -. [Q9H6R7-1]
DR CCDS; CCDS46229.1; -. [Q9H6R7-2]
DR RefSeq; NP_001135791.1; NM_001142319.1. [Q9H6R7-2]
DR RefSeq; NP_079479.1; NM_025203.2. [Q9H6R7-1]
DR AlphaFoldDB; Q9H6R7; -.
DR BioGRID; 123217; 88.
DR IntAct; Q9H6R7; 57.
DR MINT; Q9H6R7; -.
DR STRING; 9606.ENSP00000295148; -.
DR GlyGen; Q9H6R7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H6R7; -.
DR PhosphoSitePlus; Q9H6R7; -.
DR BioMuta; WDCP; -.
DR DMDM; 74752699; -.
DR EPD; Q9H6R7; -.
DR jPOST; Q9H6R7; -.
DR MassIVE; Q9H6R7; -.
DR MaxQB; Q9H6R7; -.
DR PaxDb; Q9H6R7; -.
DR PeptideAtlas; Q9H6R7; -.
DR PRIDE; Q9H6R7; -.
DR ProteomicsDB; 81022; -. [Q9H6R7-1]
DR ProteomicsDB; 81023; -. [Q9H6R7-2]
DR ProteomicsDB; 81024; -. [Q9H6R7-3]
DR Antibodypedia; 51026; 71 antibodies from 13 providers.
DR DNASU; 80304; -.
DR Ensembl; ENST00000295148.9; ENSP00000295148.4; ENSG00000163026.12. [Q9H6R7-1]
DR Ensembl; ENST00000406895.3; ENSP00000385816.3; ENSG00000163026.12. [Q9H6R7-2]
DR GeneID; 80304; -.
DR KEGG; hsa:80304; -.
DR MANE-Select; ENST00000295148.9; ENSP00000295148.4; NM_025203.3; NP_079479.1.
DR UCSC; uc002rep.3; human. [Q9H6R7-1]
DR CTD; 80304; -.
DR DisGeNET; 80304; -.
DR GeneCards; WDCP; -.
DR HGNC; HGNC:26157; WDCP.
DR HPA; ENSG00000163026; Low tissue specificity.
DR MIM; 616234; gene.
DR neXtProt; NX_Q9H6R7; -.
DR OpenTargets; ENSG00000163026; -.
DR PharmGKB; PA147358716; -.
DR VEuPathDB; HostDB:ENSG00000163026; -.
DR eggNOG; ENOG502QUUX; Eukaryota.
DR GeneTree; ENSGT00390000001660; -.
DR HOGENOM; CLU_025195_0_0_1; -.
DR InParanoid; Q9H6R7; -.
DR OMA; TIWQLCF; -.
DR OrthoDB; 435947at2759; -.
DR PhylomeDB; Q9H6R7; -.
DR TreeFam; TF333528; -.
DR PathwayCommons; Q9H6R7; -.
DR Reactome; R-HSA-9725370; Signaling by ALK fusions and activated point mutants.
DR SignaLink; Q9H6R7; -.
DR BioGRID-ORCS; 80304; 19 hits in 1055 CRISPR screens.
DR GenomeRNAi; 80304; -.
DR Pharos; Q9H6R7; Tdark.
DR PRO; PR:Q9H6R7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9H6R7; protein.
DR Bgee; ENSG00000163026; Expressed in secondary oocyte and 112 other tissues.
DR ExpressionAtlas; Q9H6R7; baseline and differential.
DR Genevisible; Q9H6R7; HS.
DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR GO; GO:0051259; P:protein complex oligomerization; IDA:UniProtKB.
DR InterPro; IPR028041; WDCP.
DR PANTHER; PTHR14897; PTHR14897; 1.
DR Pfam; PF15390; WDCP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Chromosomal rearrangement; Coiled coil;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..721
FT /note="WD repeat and coiled-coil-containing protein"
FT /id="PRO_0000299501"
FT REPEAT 55..98
FT /note="WD 1"
FT REPEAT 154..194
FT /note="WD 2"
FT REGION 520..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..545
FT /note="Interaction with HCK"
FT /evidence="ECO:0000269|PubMed:25469238"
FT COILED 556..584
FT /evidence="ECO:0000255"
FT COMPBIAS 522..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 299
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 468
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 501
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT MOD_RES 523
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT MOD_RES 530
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 686
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 690
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..487
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_027712"
FT VAR_SEQ 488
FT /note="N -> M (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_027715"
FT VAR_SEQ 607..622
FT /note="KPYYLGPVVEKRAVLL -> IPTGFFSLLTVRALSR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027713"
FT VAR_SEQ 623..721
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027714"
FT VARIANT 102
FT /note="T -> M (in dbSNP:rs3731620)"
FT /id="VAR_034834"
FT VARIANT 454
FT /note="P -> S (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035876"
FT MUTAGEN 540
FT /note="P->A: Loss of interaction with HCK; when associated
FT with P-543."
FT /evidence="ECO:0000269|PubMed:25469238"
FT MUTAGEN 543
FT /note="P->A: Loss of interaction with HCK; when associated
FT with P-543."
FT /evidence="ECO:0000269|PubMed:25469238"
SQ SEQUENCE 721 AA; 79136 MW; 4A4164C81A693DAE CRC64;
MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV
CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV
WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH
SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP
PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT
CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD
QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL
TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP
RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI
PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM
A
