WDCP_MOUSE
ID WDCP_MOUSE Reviewed; 663 AA.
AC Q6NV72; Q3U2S5; Q8C9V8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=WD repeat and coiled-coil-containing protein {ECO:0000305};
GN Name=Wdcp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=129/Sv X 129SvCp; TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Oligomer. Interacts with HCK (via SH3 domain).
CC {ECO:0000250|UniProtKB:Q9H6R7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NV72-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NV72-2; Sequence=VSP_027716;
CC -!- PTM: Phosphorylated on Tyr when associated with HCK.
CC {ECO:0000250|UniProtKB:Q9H6R7}.
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DR EMBL; AK040407; BAC30587.1; -; mRNA.
DR EMBL; AK155130; BAE33065.1; -; mRNA.
DR EMBL; BC068281; AAH68281.1; -; mRNA.
DR CCDS; CCDS25793.1; -. [Q6NV72-2]
DR CCDS; CCDS49019.1; -. [Q6NV72-1]
DR RefSeq; NP_001164329.1; NM_001170858.1. [Q6NV72-1]
DR RefSeq; NP_775592.2; NM_173416.3. [Q6NV72-2]
DR RefSeq; XP_017170539.1; XM_017315050.1. [Q6NV72-1]
DR AlphaFoldDB; Q6NV72; -.
DR SMR; Q6NV72; -.
DR IntAct; Q6NV72; 2.
DR MINT; Q6NV72; -.
DR STRING; 10090.ENSMUSP00000082948; -.
DR iPTMnet; Q6NV72; -.
DR PhosphoSitePlus; Q6NV72; -.
DR EPD; Q6NV72; -.
DR MaxQB; Q6NV72; -.
DR PaxDb; Q6NV72; -.
DR PRIDE; Q6NV72; -.
DR ProteomicsDB; 299964; -. [Q6NV72-1]
DR ProteomicsDB; 299965; -. [Q6NV72-2]
DR Antibodypedia; 51026; 71 antibodies from 13 providers.
DR DNASU; 238037; -.
DR Ensembl; ENSMUST00000053034; ENSMUSP00000054102; ENSMUSG00000051721. [Q6NV72-2]
DR Ensembl; ENSMUST00000085793; ENSMUSP00000082948; ENSMUSG00000051721. [Q6NV72-1]
DR Ensembl; ENSMUST00000220215; ENSMUSP00000151585; ENSMUSG00000051721. [Q6NV72-1]
DR GeneID; 238037; -.
DR KEGG; mmu:238037; -.
DR UCSC; uc007myl.2; mouse. [Q6NV72-1]
DR UCSC; uc007mym.2; mouse. [Q6NV72-2]
DR CTD; 80304; -.
DR MGI; MGI:3040699; Wdcp.
DR VEuPathDB; HostDB:ENSMUSG00000051721; -.
DR eggNOG; ENOG502QUUX; Eukaryota.
DR GeneTree; ENSGT00390000001660; -.
DR HOGENOM; CLU_025195_0_0_1; -.
DR InParanoid; Q6NV72; -.
DR PhylomeDB; Q6NV72; -.
DR TreeFam; TF333528; -.
DR BioGRID-ORCS; 238037; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Wdcp; mouse.
DR PRO; PR:Q6NV72; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q6NV72; protein.
DR Bgee; ENSMUSG00000051721; Expressed in yolk sac and 91 other tissues.
DR ExpressionAtlas; Q6NV72; baseline and differential.
DR Genevisible; Q6NV72; MM.
DR GO; GO:0019900; F:kinase binding; ISO:MGI.
DR GO; GO:0051259; P:protein complex oligomerization; ISO:MGI.
DR InterPro; IPR028041; WDCP.
DR PANTHER; PTHR14897; PTHR14897; 1.
DR Pfam; PF15390; WDCP; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Coiled coil; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..663
FT /note="WD repeat and coiled-coil-containing protein"
FT /id="PRO_0000299502"
FT REPEAT 55..98
FT /note="WD 1"
FT REPEAT 154..194
FT /note="WD 2"
FT REGION 454..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..538
FT /note="Interaction with HCK"
FT /evidence="ECO:0000250|UniProtKB:Q9H6R7"
FT COILED 549..577
FT /evidence="ECO:0000255"
FT COMPBIAS 457..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6R7"
FT MOD_RES 291
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6R7"
FT MOD_RES 460
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6R7"
FT MOD_RES 493
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6R7"
FT MOD_RES 524
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6R7"
FT VAR_SEQ 600..663
FT /note="NPCSVGPTERRAVLLCDGKLRLSTVQQMFGLHLVEMLHEVLSSIPSNHMVTH
FT NLHGPGGLFWSV -> VQSFLRNFHYTGSSGIQSVLPATLWGRWGGRESEAQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027716"
FT CONFLICT 150
FT /note="K -> T (in Ref. 2; AAH68281)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="S -> F (in Ref. 1; BAC30587)"
FT /evidence="ECO:0000305"
FT CONFLICT 485
FT /note="R -> G (in Ref. 2; AAH68281)"
FT /evidence="ECO:0000305"
FT CONFLICT 567
FT /note="Y -> H (in Ref. 2; AAH68281)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 663 AA; 72268 MW; 62F299D3325A4D42 CRC64;
MELGNGKLPR TGLNSLNQAV HPTWGLAWTD GNRVVLTDLQ LHSGEAKFGD SRVIGRFESV
CGVCWAPVRT VRSPALLAIQ HRKLVSVWQL CPSTAGASKW QASQTSEVRE SLPILPRGCV
WHPKDAVLTV LTAQGVSIFP NVHQDGSRVK VDVNTKGRVY CACWTLDGQR LVVAIDSNLH
SYIWDSSQKS LHSCSFCPVF PVNCSIRSIE ATGNSQVAIA TELPLHKLCS LNASEALDGP
PNGDDGSVHT RPVDEQVATM DMNSGVTVSP FSVPLDLTHI HFNPSQAEQS SLICLRKKDY
LTGTGQDSSH LILVTFKKAI TITKKVAIPG ILVPDLIAFN LTAELVAVAS NTCNVILIYS
AAPSSMPNIQ QIQLESNERP KGICFLTDRL LLIAVGKQKP SEAAFLPSSE YGQYTVRLIV
REMAQGSESS GTSAESQGAY SDFTALLSKA DREKFTDSLS PGSSPLSQGL LLTPNSSTQS
GRSGRALIQE IKSPLSPLSS DSVVHETLHR PPWLCPALPR PSRTPEHTST PELNSPQREN
LQKEKETCPL SRELEILSRH LVAMQQYLSE LTGFLHKEKR VAPAYPPSQD APYVHLIYQN
PCSVGPTERR AVLLCDGKLR LSTVQQMFGL HLVEMLHEVL SSIPSNHMVT HNLHGPGGLF
WSV
