WDFY2_CAEBR
ID WDFY2_CAEBR Reviewed; 417 AA.
AC A8XXC7;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=WD repeat and FYVE domain-containing protein 2 {ECO:0000250|UniProtKB:Q18964};
GN Name=wdfy-2 {ECO:0000250|UniProtKB:Q18964}; ORFNames=CBG20231;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Plays a role in coelomocyte endocytosis.
CC {ECO:0000250|UniProtKB:Q18964}.
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DR EMBL; HE601386; CAP37296.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XXC7; -.
DR SMR; A8XXC7; -.
DR STRING; 6238.CBG20231; -.
DR EnsemblMetazoa; CBG20231.1; CBG20231.1; WBGene00039267.
DR WormBase; CBG20231; CBP29678; WBGene00039267; Cbr-wdfy-2.
DR eggNOG; KOG1409; Eukaryota.
DR HOGENOM; CLU_046919_0_0_1; -.
DR InParanoid; A8XXC7; -.
DR OMA; RCCDPCY; -.
DR OrthoDB; 555190at2759; -.
DR Proteomes; UP000008549; Chromosome II.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR042234; WDFY1/WDFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46189; PTHR46189; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Endocytosis; Metal-binding; Reference proteome; Repeat; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..417
FT /note="WD repeat and FYVE domain-containing protein 2"
FT /id="PRO_0000356226"
FT REPEAT 29..68
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 119..157
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 202..241
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 245..284
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 373..412
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT ZN_FING 286..357
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 292
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 295
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 319
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 322
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 327
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 330
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 349
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 352
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
SQ SEQUENCE 417 AA; 46221 MW; A93DB03DD718527E CRC64;
MAAIINQRVD QGESSMGGAK PTLLHKIAGH VARINDVILL SKDEGVWTAS DDRSVRLYLK
RDNDQFWPSI HHFMPVAPTC LFYSEETYKL LVGLINGNVY EFNVADDFNS MTESRKWTCH
AGPISGLGFA LSSELIFSCS RDKSIVWHCS ENSNKVGSYL LENSCTAMVI DLPFVFVGDH
GGHVTVLRII DNQPNLVSKL SAHTNSITSL TWDGNKKVLY SGSSDHLIIM WDIGGGKGEA
YELNGHNGKV TTLCAAPAAK RLFSADEHGK LMCWDMDVRR VETPEWKTSD CCQKCNQPFF
WNLQAMWQRK VVGLRQHHCR TCGSAVCGSC CDNWTTYPPM GYETKVRICN DCAGRMKENP
GNFDLTPLAI PHEIRTGITA MHLQETLGLL VTSGQNRVVM IWDVRSVCSA PSGSGGH
