WDFY2_CAEEL
ID WDFY2_CAEEL Reviewed; 415 AA.
AC Q18964;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=WD repeat and FYVE domain-containing protein 2;
GN Name=wdfy-2; ORFNames=D2013.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16873553; DOI=10.1073/pnas.0508832103;
RA Hayakawa A., Leonard D., Murphy S., Hayes S., Soto M., Fogarty K.,
RA Standley C., Bellve K., Lambright D., Mello C., Corvera S.;
RT "The WD40 and FYVE domain containing protein 2 defines a class of early
RT endosomes necessary for endocytosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11928-11933(2006).
CC -!- FUNCTION: Plays a role in coelomocyte endocytosis.
CC {ECO:0000269|PubMed:16873553}.
CC -!- INTERACTION:
CC Q18964; P34296: C06E1.1; NbExp=3; IntAct=EBI-314363, EBI-318589;
CC Q18964; H2KZJ7: praf-3; NbExp=3; IntAct=EBI-314363, EBI-318599;
CC -!- DISRUPTION PHENOTYPE: Worms exhibit disruption of coelomocyte
CC endocytosis. {ECO:0000269|PubMed:16873553}.
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DR EMBL; Z47808; CAA87770.1; -; Genomic_DNA.
DR PIR; T20335; T20335.
DR RefSeq; NP_495983.1; NM_063582.3.
DR AlphaFoldDB; Q18964; -.
DR SMR; Q18964; -.
DR BioGRID; 39799; 20.
DR DIP; DIP-26372N; -.
DR IntAct; Q18964; 12.
DR STRING; 6239.D2013.2.1; -.
DR EPD; Q18964; -.
DR PaxDb; Q18964; -.
DR PeptideAtlas; Q18964; -.
DR EnsemblMetazoa; D2013.2.1; D2013.2.1; WBGene00008402.
DR GeneID; 174475; -.
DR KEGG; cel:CELE_D2013.2; -.
DR CTD; 174475; -.
DR WormBase; D2013.2; CE00928; WBGene00008402; wdfy-2.
DR eggNOG; KOG1409; Eukaryota.
DR GeneTree; ENSGT00940000169431; -.
DR HOGENOM; CLU_046919_0_0_1; -.
DR InParanoid; Q18964; -.
DR OMA; RCCDPCY; -.
DR OrthoDB; 555190at2759; -.
DR PhylomeDB; Q18964; -.
DR PRO; PR:Q18964; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00008402; Expressed in embryo and 4 other tissues.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.
DR GO; GO:0006897; P:endocytosis; IMP:WormBase.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR042234; WDFY1/WDFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46189; PTHR46189; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Endocytosis; Metal-binding; Reference proteome; Repeat; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..415
FT /note="WD repeat and FYVE domain-containing protein 2"
FT /id="PRO_0000051504"
FT REPEAT 71..103
FT /note="WD 1"
FT REPEAT 119..148
FT /note="WD 2"
FT REPEAT 202..232
FT /note="WD 3"
FT REPEAT 245..284
FT /note="WD 4"
FT REPEAT 373..403
FT /note="WD 5"
FT ZN_FING 286..357
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 292
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 295
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 319
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 322
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 327
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 330
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 349
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 352
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
SQ SEQUENCE 415 AA; 46240 MW; 8927612C040F5E43 CRC64;
MAAIINQRVE QGESSMGGAK PALLHRITGH VARINDVILL SKDEGVWTAS DDRSVRLYLK
RDNDQFWPSI HHFMPVAPTS LYYSEETYKL LVGLINGNVY EFSVADDFNS MTESRKWTCH
AGPISGLGFA LSSELIFSCS RDKSIVWHCS ENSNKMGSYL LENSCTAMVI DLPFVFVGDH
GGHVTVLRIV DNQPNLVSKL SAHTNAITSL TWDGNKKVLY SGSSDHLIIM WDIGGGRGEA
YELNGHNGKV TTLCAAPAAK RLFSADEHGK LMCWDMNCKR VETPEWKTSD CCQKCNQPFF
WNLQAMWQRK VVGLRQHHCR TCGSAVCGSC CDNWTTYPPM GYETKIRICN DCNARMKDNP
QNFNLTPLAI PHEIHTGITA MHLQETLGLL VTSGQNRVIM IWDVRSVCSA PSGSQ
