ID   WDHD1_XENLA             Reviewed;        1127 AA.
AC   O13046;
DT   22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=WD repeat and HMG-box DNA-binding protein 1;
DE   AltName: Full=Acidic nucleoplasmic DNA-binding protein 1;
DE            Short=And-1;
GN   Name=wdhd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, SUBUNIT, AND DNA-BINDING.
RC   TISSUE=Oocyte;
RX   PubMed=9175701; DOI=10.1242/jcs.110.9.1051;
RA   Koehler A., Schmidt-Zachmann M.S., Franke W.W.;
RT   "AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with
RT   regulatory WD-repeats.";
RL   J. Cell Sci. 110:1051-1062(1997).
CC   -!- FUNCTION: Acts as a replication initiation factor that brings together
CC       the MCM2-7 helicase and the DNA polymerase alpha/primase complex in
CC       order to initiate DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305|PubMed:9175701}.
CC   -!- INTERACTION:
CC       O13046; Q9DE46: pola1; NbExp=2; IntAct=EBI-3510652, EBI-3645423;
CC       O13046; Q0IHI4: tipin; NbExp=5; IntAct=EBI-3510652, EBI-7570880;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000269|PubMed:9175701}. Cytoplasm {ECO:0000269|PubMed:9175701}.
CC       Note=Transiently cytoplasmic during mitosis.
CC   -!- TISSUE SPECIFICITY: Found in oocytes and in various other cells.
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DR   EMBL; X98884; CAA67387.1; -; mRNA.
DR   PIR; T30334; T30334.
DR   AlphaFoldDB; O13046; -.
DR   SMR; O13046; -.
DR   IntAct; O13046; 5.
DR   MINT; O13046; -.
DR   PRIDE; O13046; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR022100; Mcl1_mid.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08662; eIF2A; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12341; Mcl1_mid; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00398; HMG; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1127
FT                   /note="WD repeat and HMG-box DNA-binding protein 1"
FT                   /id="PRO_0000051340"
FT   REPEAT          11..50
FT                   /note="WD 1"
FT   REPEAT          52..91
FT                   /note="WD 2"
FT   REPEAT          92..131
FT                   /note="WD 3"
FT   REPEAT          134..173
FT                   /note="WD 4"
FT   REPEAT          184..223
FT                   /note="WD 5"
FT   REPEAT          228..267
FT                   /note="WD 6"
FT   REPEAT          271..310
FT                   /note="WD 7"
FT   DNA_BIND        1013..1076
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          811..1013
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1064..1127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..875
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        878..938
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1064..1086
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1127 AA;  124650 MW;  4F4C4A3FC7422082 CRC64;
     MPAIKKNMRY GHPEGHTDVC FDDSGNFLVT CGSDGDIRIW ESLDDDDPKS ISIGEKAYSF
     ALKNGKVVTA ASNNAIQLHT FPDGEPDGIL TRFTTNANHV VFNTDGTRIA AGSGDFLVKV
     LQVEDSTQQK TLRGHSAPVL SVSFDPKDIY LASASCDGSV RIWKISDQTC EAVLPLLEKC
     NDVFNAKSIC RLAWQPKSGK FVAIPVGKAV HLYDRDSLKN ICTLSDDFIT QPVNIVAWSP
     CGQYLVAGSV DGCIVAWNIA TKACLERIKH EKGYTICALA WHPHLPQIAY TDNEGNLGLL
     EDVCQGDVKQ PSAKVSSAET KDYDELFDGD DDEDFLNGDM IGHEGAVNDE DDDDNFTALT
     GRPRNRGAIF DDDISSDVPS LKLVGNENPV VEDDQASSVQ NFTSVASVKL SYNGPMPTPQ
     QKPFQSGSTP VHLMHRFMVW NSVGVIRCYN DEQDNAIDVE FHDTSIHHAI HLTNSLNHTL
     ADVSQEAVLL ACETTEELAS KLQCLHFSSW DTSKEWMVDM PKGENIQAIC LGQGWVACAT
     SALLIRIFSV GGVQKELISL FGPVVCMASH GEQLIVVYHR GMGFDGDQCL GVQLLELGKK
     KKQVLHGDPL PLSRKSYLSW LGFTAEGSPC YVDSEGIVRL LNRSLGDTWV PICNTREHCK
     GKSDHYWVVG IHENPQQVRC IPCKGSRFPP TLPRPAVAVL PFNLPYCQIT TEKGQMEEQY
     WRSQIFSNHS DYLSKHGYEC DENFKAEAQK MQQELLMKMF ALSCKLEREF RCMELAEFMT
     QNVMNLAIKY ASRSKRLILA QRLSEMALEK AAEQASAEQN EEEDEEEEDF RSRLTAGYSR
     TATEWGDSRA KPVKQDQYEE NNEEEMEEEE KEQEEALESN TPTANPFNKS VKTPDVSESK
     LGAILSSNQG RVNPFKVSAS QKSPAFASNS SRSTSILDNM GKFPRKPSAS GSPSTSKSDS
     VIIKPLAPKA KSKQGQATLF HSVQAKPIAK KTTEEKKAVP TPPKAAADIA ENKKPKTGFQ
     LWLDENRPSI LSENAGLDES EIIKEGMSRF RMLTSEERML WTEKAKGDYP GEDGADAKKR
     KRPEQENMAS NGCPQENTDS GIAAAKKHKP LGQSANNKLS AFAFKKE