ID   CAMP_CAMAN              Reviewed;          15 AA.
AC   P0DW50;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Beta-campsomerin {ECO:0000303|PubMed:34941722};
DE   AltName: Full=Bradykinin-related peptide {ECO:0000303|PubMed:34941722};
DE   Contains:
DE     RecName: Full=Alpha-campsomerin {ECO:0000303|PubMed:34941722};
OS   Campsomeriella annulata (Wasp) (Campsomeris annulata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Scolioidea;
OC   Scoliidae; Campsomeriella.
OX   NCBI_TaxID=1574124;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   SYNTHESIS OF ALPHA AND BETA-CAMPSOMERIN.
RC   TISSUE=Venom;
RX   PubMed=34941722; DOI=10.3390/toxins13120885;
RA   Alberto-Silva C., Vieira Portaro F.C., Kodama R.T., Pantaleao H.Q.,
RA   Inagaki H., Nihei K.I., Konno K.;
RT   "Comprehensive analysis and biological characterization of venom components
RT   from solitary scoliid wasp a annulata annulata.";
RL   Toxins 13:0-0(2021).
CC   -!- FUNCTION: [Alpha-campsomerin]: Shows cell viability potentiating effect
CC       in neuronal PC12 cells. Does not show neuroprotective benefits against
CC       H2O2-induced oxidative stress in PC12 neuronal cells. Has no effects on
CC       metallopeptidases (human neprilysin (NEP) and angiotensin-converting
CC       enzyme (ACE)) and acetylcholinesterase (AChE), and has no cytotoxic
CC       effects. {ECO:0000269|PubMed:34941722}.
CC   -!- FUNCTION: [Beta-campsomerin]: Does not show cell viability potentiating
CC       effect in neuronal PC12 cells. Does not show neuroprotective benefits
CC       against H2O2-induced oxidative stress in PC12 neuronal cells. Has no
CC       effects on metallopeptidases (human neprilysin (NEP) and angiotensin-
CC       converting enzyme (ACE)) and acetylcholinesterase (AChE), and has no
CC       cytotoxic effects. {ECO:0000269|PubMed:34941722}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34941722}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:34941722}.
CC   -!- MASS SPECTROMETRY: [Alpha-campsomerin]: Mass=1534.86;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:34941722};
CC   -!- MASS SPECTROMETRY: [Beta-campsomerin]: Mass=1702.95;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:34941722};
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..15
FT                   /note="Beta-campsomerin"
FT                   /evidence="ECO:0000269|PubMed:34941722"
FT                   /id="PRO_0000456298"
FT   PEPTIDE         1..13
FT                   /note="Alpha-campsomerin"
FT                   /evidence="ECO:0000269|PubMed:34941722"
FT                   /id="PRO_0000456299"
SQ   SEQUENCE   15 AA;  1703 MW;  2C37FFDAF34E6838 CRC64;
     PRLRRLTGLS PLRAP