WDR12_AEDAE
ID WDR12_AEDAE Reviewed; 427 AA.
AC Q17BB0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN ORFNames=AAEL005041;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH477324; EAT43536.1; -; Genomic_DNA.
DR RefSeq; XP_001650205.1; XM_001650155.1.
DR AlphaFoldDB; Q17BB0; -.
DR SMR; Q17BB0; -.
DR STRING; 7159.AAEL005041-PA; -.
DR GeneID; 5565845; -.
DR KEGG; aag:5565845; -.
DR VEuPathDB; VectorBase:AAEL005041; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; Q17BB0; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR PhylomeDB; Q17BB0; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..427
FT /note="Ribosome biogenesis protein WDR12 homolog"
FT /id="PRO_0000369552"
FT REPEAT 109..146
FT /note="WD 1"
FT REPEAT 148..190
FT /note="WD 2"
FT REPEAT 197..236
FT /note="WD 3"
FT REPEAT 260..298
FT /note="WD 4"
FT REPEAT 301..339
FT /note="WD 5"
FT REPEAT 345..385
FT /note="WD 6"
FT REPEAT 389..427
FT /note="WD 7"
FT REGION 13..97
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ SEQUENCE 427 AA; 48115 MW; 233A79851D156554 CRC64;
MALKITGKSE GQLQLHLYTK QKQFAVPDVP YSIRANVSNK ELNVLINTLL KDSGNSEAGK
VEFDFLLNGE FVKIPLGQHL KEREISFEDT VELEYVERYP APEPQDCLLH DDWVSAVEAK
DNWILTGCYD NTLNIWTTKG KHKLTIPGHI APVKGVTWIS LDEEKGVFAS ASQDQTVMLW
EWNVKANSVE CVQVCKGHER GVDCIAANRS KTRMATGSWD TMLKIWSTDV RNDGDSQPST
SKRQKLDTEK ARTPVLTLAG HRECISGVQW IDDNTLVTSS WDHTIKIWDL ALSGIKSEIC
GHKSFFDLSY SHLNGLIIAA SPDKNLRLYD PKSNQGTIVK NTYLGHTQWV QSVRWSTTNE
YLFVSGAYDN HVKLWDYRSP KAPIFELIGH EDKVLACDWS NPKFILSGGS DNSVRVFKSK
IAIGEQK
