ID   WDR12_CAEBR             Reviewed;         446 AA.
AC   A8XL02;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=wdr-12 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Synonyms=tag-345 {ECO:0000312|WormBase:CBG14922};
GN   ORFNames=CBG14922 {ECO:0000312|WormBase:CBG14922};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE600904; CAP33326.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XL02; -.
DR   SMR; A8XL02; -.
DR   STRING; 6238.CBG14922; -.
DR   WormBase; CBG14922; CBP18128; WBGene00035296; Cbr-wdr-12.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; A8XL02; -.
DR   OMA; PKPLHDI; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..446
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369551"
FT   REPEAT          171..211
FT                   /note="WD 1"
FT   REPEAT          216..255
FT                   /note="WD 2"
FT   REPEAT          284..324
FT                   /note="WD 3"
FT   REPEAT          326..365
FT                   /note="WD 4"
FT   REPEAT          371..412
FT                   /note="WD 5"
FT   REPEAT          416..446
FT                   /note="WD 6"
FT   REGION          21..105
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          256..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  49755 MW;  2A5FB900644A82BD CRC64;
     MDLSESMEVD NGTTSENLKH VQITFFSKDK DLPEIPDAVF DVPTVAECDD LNLLLNKTIQ
     ATDDAWKEKK FEFLVGETFL RTSLAEFIEE YEVETETILK IECIIGIEAP KPLHDIQAPD
     WVSSVQVANG HTKSTNLFSI FSTTYGGDIV IVDRKGKETK LSVNSANRIL KCSGIVRTTK
     KVQLEGTEFI VGGENQLLTL YEIEKGALVE KIVFRGHERA VECVSVNSDA TRAISGSVDT
     NLKVWNLDPS DEATIYEKEE EESSAKKKRK KDTRTKVPMV TIGGHRDKVS SVVWCPWKSG
     HAFSCSWDHT VVQWDLELAG EVSRIKGPKS FTSIDIHPTS NLLISSCTDA IPRLYDPKNR
     DGAMVKQSFI GHQNGWVESV KWNPVDENQF VSVSTDKTAK MWDVRSSKSS LFDIHGHEDR
     ILCAAWNEGL IATGSADCSI KIFETS