ID   WDR12_CAEEL             Reviewed;         439 AA.
AC   P91343;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=wdr-12 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Synonyms=tag-345 {ECO:0000312|WormBase:F55F8.5};
GN   ORFNames=F55F8.5 {ECO:0000312|WormBase:F55F8.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; FO081477; CCD71887.1; -; Genomic_DNA.
DR   PIR; T29587; T29587.
DR   RefSeq; NP_491655.1; NM_059254.5.
DR   AlphaFoldDB; P91343; -.
DR   SMR; P91343; -.
DR   BioGRID; 37684; 7.
DR   STRING; 6239.F55F8.5.1; -.
DR   EPD; P91343; -.
DR   PaxDb; P91343; -.
DR   PeptideAtlas; P91343; -.
DR   EnsemblMetazoa; F55F8.5.1; F55F8.5.1; WBGene00018893.
DR   GeneID; 172226; -.
DR   KEGG; cel:CELE_F55F8.5; -.
DR   UCSC; F55F8.5.1; c. elegans.
DR   CTD; 172226; -.
DR   WormBase; F55F8.5; CE11196; WBGene00018893; wdr-12.
DR   eggNOG; KOG0313; Eukaryota.
DR   GeneTree; ENSGT00930000150950; -.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; P91343; -.
DR   OMA; PKPLHDI; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; P91343; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:P91343; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00018893; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..439
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000051505"
FT   REPEAT          117..154
FT                   /note="WD 1"
FT   REPEAT          160..204
FT                   /note="WD 2"
FT   REPEAT          209..248
FT                   /note="WD 3"
FT   REPEAT          277..317
FT                   /note="WD 4"
FT   REPEAT          319..358
FT                   /note="WD 5"
FT   REPEAT          364..405
FT                   /note="WD 6"
FT   REPEAT          409..439
FT                   /note="WD 7"
FT   REGION          21..105
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          248..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   439 AA;  49002 MW;  85048D62E155E31C CRC64;
     MDLADLMEVE NGDHSINQKH VQITFFSKDE EIPQIPDAVF DVPTGAECDD MNLLLNKTIE
     ANDGAWKERR FEFLVGETFL RTSLAEFIEE YEVETETILK VECVIGIEAP KPLHDIQAPD
     WVSSVQIANG HIFSTTYGGD IVIVDRKGKE TKLAVNSANR LLKCISIVKA PSKKNQLDGT
     EFVVGGENQL LTLYAIEKGA LVEKLILRGH ERAVECVSVN SDSTRAISGS VDTNLKIWNL
     DASDEATTYE KEEEEESAKK RRKKETKTKV PMVTIGGHRD KVSAVEWCPW NSGHAFSCSW
     DHTIVEWDLE LAGEISRIKG PKSFTSIDLH PKSDLLISSC TDAIPRLYDP KNRDGSMVKQ
     SFIGHQNGWV EAVKWNPLDT NQFVSVSTDK TAKMWDVRSS KSSLFDIHGH DDRILCATWN
     EGLIATGSAD CTIKIFETA