WDR12_DANRE
ID WDR12_DANRE Reviewed; 422 AA.
AC Q6NX08; Q803T7;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Ribosome biogenesis protein wdr12 {ECO:0000255|HAMAP-Rule:MF_03029};
DE AltName: Full=WD repeat-containing protein 12 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=wdr12;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and
CC wdr12. The complex is held together by bop1, which interacts with pes1
CC via its N-terminal domain and with wdr12 via a high-affinity
CC interaction between the seven-bladed beta-propeller domains of the 2
CC proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC Interacts (via UBL domain) with mdn1 (via VWFA/MIDAS domain).
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; BC044198; AAH44198.1; -; mRNA.
DR EMBL; BC067331; AAH67331.1; -; mRNA.
DR EMBL; BC155268; AAI55269.1; -; mRNA.
DR RefSeq; NP_955851.1; NM_199557.1.
DR AlphaFoldDB; Q6NX08; -.
DR SMR; Q6NX08; -.
DR STRING; 7955.ENSDARP00000004327; -.
DR PaxDb; Q6NX08; -.
DR DNASU; 321652; -.
DR Ensembl; ENSDART00000012903; ENSDARP00000004327; ENSDARG00000003287.
DR GeneID; 321652; -.
DR KEGG; dre:321652; -.
DR CTD; 55759; -.
DR ZFIN; ZDB-GENE-030131-371; wdr12.
DR eggNOG; KOG0313; Eukaryota.
DR GeneTree; ENSGT00930000150950; -.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; Q6NX08; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR PhylomeDB; Q6NX08; -.
DR TreeFam; TF313023; -.
DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q6NX08; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000003287; Expressed in somite and 42 other tissues.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; ISS:UniProtKB.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..422
FT /note="Ribosome biogenesis protein wdr12"
FT /id="PRO_0000354081"
FT REPEAT 99..136
FT /note="WD 1"
FT REPEAT 138..180
FT /note="WD 2"
FT REPEAT 187..226
FT /note="WD 3"
FT REPEAT 254..292
FT /note="WD 4"
FT REPEAT 294..333
FT /note="WD 5"
FT REPEAT 339..379
FT /note="WD 6"
FT REPEAT 383..421
FT /note="WD 7"
FT REGION 4..87
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 220..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 231
FT /note="N -> D (in Ref. 1; AAH44198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 47281 MW; 876368628F120878 CRC64;
MSQLQARFFT ENKKYLVDDV PFSIPASSEV ADLSGVINKL LEAKNAGHKH VEFDFLVRGQ
FLRTSLDKHI ETENISTEEV VEIEYVEKFT APQPEECIMH DDWISSVEAD SEWILTGSYD
KTARIWSMEG KAVMTVAGHA DVVKDVAWVK RDGLNSVLLT ASLDQTVMLW EWNSERNKVK
ARHCCRGHAG SVDTIAVDPT RTKFCSGSWD KMLKIWSAVP TEEEDEIEEP NRPRKKQKTE
QMGLTRTPLM TLSGHNEAVS SVLWMDADEL CSASWDHTIR LWDAETGGQK STLSGSKVFN
CISYSPLCRR LASGSTDRHV RLWDPRSKDG SLVLLSLTSH NGWVTAVRWA PSHEHQLVSG
SLDNVVKLWD TRSCKAPLYD LAAHEDKVLC ADWTENGLIL SGGADNKLYT YRYAACVSDA
GA
