ID   WDR12_DROAN             Reviewed;         419 AA.
AC   B3MJV8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GF14067;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH902620; EDV32413.1; -; Genomic_DNA.
DR   RefSeq; XP_001963192.1; XM_001963156.2.
DR   AlphaFoldDB; B3MJV8; -.
DR   SMR; B3MJV8; -.
DR   STRING; 7217.FBpp0117259; -.
DR   EnsemblMetazoa; FBtr0118767; FBpp0117259; FBgn0091094.
DR   GeneID; 6496895; -.
DR   KEGG; dan:6496895; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; B3MJV8; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B3MJV8; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..419
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369555"
FT   REPEAT          103..141
FT                   /note="WD 1"
FT   REPEAT          142..184
FT                   /note="WD 2"
FT   REPEAT          191..230
FT                   /note="WD 3"
FT   REPEAT          249..287
FT                   /note="WD 4"
FT   REPEAT          289..328
FT                   /note="WD 5"
FT   REPEAT          334..374
FT                   /note="WD 6"
FT   REPEAT          378..416
FT                   /note="WD 7"
FT   REGION          10..91
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   419 AA;  46944 MW;  48C4AB02583EAE7F CRC64;
     MDVENGEGQV QVHLKTKQEH YAVPDVPYAI DGTVTTAELN TFVNTLLQQK DGSPVDFDFL
     VFDEYLRGRL CDHLREKAIS FEDAIEIEYV ERFPAPEPQD CLLHDDWVSA VKANGKWILT
     GCYDNTLNIW TNKGKHILTI SGHTAPIKAV DWISLDEESG RFVSSSQDQT AMLWQWNVGS
     NTAECVSVCK GHERGVDSVS VSPDGQRFAT GSWDTMLKVW SAELDDAGEG TSKRMKESGV
     RTPKMTLQGH RESISAVQWM DASTLLTGSW DHTLKVWDLS LEGIKTEIST NKSIFDASYS
     NLNRLIVTAS ADKNLRLYDA RTNQGSVVRN TYLGHNAWVQ AVMWSTTEEF LFVSGAYDNQ
     NKLWDCRSPK APLYDLLGHG EKVLDIDWTN PKYIVSGGAD NSVRVFKSRK AVVESMDTK