ID   WDR12_DROGR             Reviewed;         419 AA.
AC   B4JPT9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GH13339;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH916372; EDV98919.1; -; Genomic_DNA.
DR   RefSeq; XP_001992994.1; XM_001992958.1.
DR   AlphaFoldDB; B4JPT9; -.
DR   SMR; B4JPT9; -.
DR   STRING; 7222.FBpp0147245; -.
DR   EnsemblMetazoa; FBtr0148753; FBpp0147245; FBgn0120815.
DR   GeneID; 6566798; -.
DR   KEGG; dgr:6566798; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; B4JPT9; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B4JPT9; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..419
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369557"
FT   REPEAT          103..141
FT                   /note="WD 1"
FT   REPEAT          142..184
FT                   /note="WD 2"
FT   REPEAT          191..230
FT                   /note="WD 3"
FT   REPEAT          249..287
FT                   /note="WD 4"
FT   REPEAT          289..328
FT                   /note="WD 5"
FT   REPEAT          334..374
FT                   /note="WD 6"
FT   REPEAT          378..416
FT                   /note="WD 7"
FT   REGION          10..91
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   419 AA;  47092 MW;  3A862A5938588BC5 CRC64;
     MEAENGEGQV QVHLKTKQEH YAVPDVPYAI EGSVSTTELN IFLNALLQNK GAASVDFDFL
     VFDEYLRGRL CDHLREKAIS FEDAIEIEYV ERFPAPEPQD CLLHDDWVSA VKASGKWILT
     GCYDNTINIW TNKGKHILTI PGHTAPIKAV DWLSLDEVNG RFVSTSQDQT AMLWQWNIDS
     NAVDCVSVCK GHERSVDSVA VSPDAQRFAT GSWDTMLKLW SAELEDAVEG SAKRAKESGV
     RTPKMTLQGH RESISAVQWM DGTTLLTGSW DHTLKVWDLN LEGIKTEIST NKSIFDANFS
     KLNRLIVTAS ADKNLRLYDP RTNQGSVVRN TYLGHNAWVQ TVMWSTTEEF LFVSGSYDNQ
     NKLWDCRSPK APLYDLLGHG EKVLDIDWSN PKYIVSGGAD NTVRVFKSRK ATVDHMETK