ID   WDR12_DROPS             Reviewed;         419 AA.
AC   Q29KQ0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GA19813;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH379061; EAL33124.1; -; Genomic_DNA.
DR   RefSeq; XP_001356065.1; XM_001356029.3.
DR   AlphaFoldDB; Q29KQ0; -.
DR   SMR; Q29KQ0; -.
DR   STRING; 7237.FBpp0287479; -.
DR   EnsemblMetazoa; FBtr0289041; FBpp0287479; FBgn0079809.
DR   GeneID; 4816649; -.
DR   KEGG; dpo:Dpse_GA19813; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; Q29KQ0; -.
DR   OMA; VDCTRTK; -.
DR   PhylomeDB; Q29KQ0; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0079809; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..419
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369561"
FT   REPEAT          103..141
FT                   /note="WD 1"
FT   REPEAT          142..184
FT                   /note="WD 2"
FT   REPEAT          191..230
FT                   /note="WD 3"
FT   REPEAT          249..287
FT                   /note="WD 4"
FT   REPEAT          289..328
FT                   /note="WD 5"
FT   REPEAT          334..374
FT                   /note="WD 6"
FT   REPEAT          378..416
FT                   /note="WD 7"
FT   REGION          10..91
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   419 AA;  46865 MW;  BB7C83B90AFED008 CRC64;
     MDVDNGEGQV QVHLKTKQEH YAVPDVPYAI DGTVTTAELN TFVNALLLSK GSSAVDFDFL
     VFDEYLRGRL CDHLREKAIS FEDAIEIEYV ERFPAPEPQD CLLHDDWVSA VKASGKWILT
     GCYDNTLNIW TNKGKHILTI PGHTAPIKAV DWISLDDDTG RFVSSSQDQT AMLWQWNVGA
     NTVECVSVCK GHERGVDSVS VSPDGQRFAT GSWDTMLKVW SAELEDAGEG TSKRMKESGV
     RTPKITLQGH RESISAVQWM DASTLLTGSW DHTLKVWDLS LEGIKAEIST NKSIFDASYS
     KLNHLILTAS ADKNLRLYDS RTNQGSVVRN TYLGHNAWVQ TVMWSTTEEF LFVSGSYDNQ
     NKLWDCRSPK APLYDLLGHG EKVLDIDWSN PKYIVSGGSD NTVRVFKSRK ALVENMDTK