ID   WDR12_DROSI             Reviewed;         420 AA.
AC   B4Q9T6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GD22226;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000361; EDX04603.1; -; Genomic_DNA.
DR   RefSeq; XP_002079018.1; XM_002078982.2.
DR   AlphaFoldDB; B4Q9T6; -.
DR   SMR; B4Q9T6; -.
DR   STRING; 7240.B4Q9T6; -.
DR   EnsemblMetazoa; FBtr0222136; FBpp0220628; FBgn0193635.
DR   GeneID; 6731883; -.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   OMA; VDCTRTK; -.
DR   PhylomeDB; B4Q9T6; -.
DR   Proteomes; UP000000304; Chromosome 2l.
DR   Bgee; FBgn0193635; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..420
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369563"
FT   REPEAT          104..142
FT                   /note="WD 1"
FT   REPEAT          143..185
FT                   /note="WD 2"
FT   REPEAT          192..231
FT                   /note="WD 3"
FT   REPEAT          250..288
FT                   /note="WD 4"
FT   REPEAT          290..329
FT                   /note="WD 5"
FT   REPEAT          335..375
FT                   /note="WD 6"
FT   REPEAT          379..417
FT                   /note="WD 7"
FT   REGION          10..92
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   420 AA;  47192 MW;  8C0C2E9C1AC03BA9 CRC64;
     MDVDNGEGQV QVHLKTKQEH YAVPDVPYAI DGTVTTVELN TFVNALLRQK DGSSDTEFDF
     LVFDEYLRGR LCDHLREKAI SFEDAIEIEY VERFPAPEPQ DCLLHDDWVS AVKARGKWIL
     SGCYDNSLNL WTNKGKHILT ISGHTAPIKA VDWISLDEET GRFVSTSQDQ TAMLWKWNVG
     SNAVDCVSVC KGHERGVDSV SVSPDGLRFA TGSWDTMLKV WSAELDDGVE GSSKRMKESG
     VRTPKITLQG HRESVSAVQW MDATTLLTGS WDYTLKVWDL SLEGIKTEIS TNKSIFDASY
     SKLNRLILTA SADKNLRLYD PRTNQGSVVR NTYLGHNAWV QTVMWSTTEE FLFVSGAYDN
     QNKLWDCRSP KAPLYDLLGH GDKVLDIDWS NPKYIVSGGV DNSVRVFKSR KALAEDTETK