ID   WDR12_DROVI             Reviewed;         419 AA.
AC   B4LS78;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GJ17641;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH940649; EDW64764.1; -; Genomic_DNA.
DR   RefSeq; XP_002052609.1; XM_002052573.2.
DR   AlphaFoldDB; B4LS78; -.
DR   SMR; B4LS78; -.
DR   STRING; 7244.FBpp0232058; -.
DR   EnsemblMetazoa; FBtr0233566; FBpp0232058; FBgn0204810.
DR   GeneID; 6629233; -.
DR   KEGG; dvi:6629233; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; B4LS78; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B4LS78; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..419
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369564"
FT   REPEAT          103..140
FT                   /note="WD 1"
FT   REPEAT          142..184
FT                   /note="WD 2"
FT   REPEAT          191..230
FT                   /note="WD 3"
FT   REPEAT          249..287
FT                   /note="WD 4"
FT   REPEAT          289..328
FT                   /note="WD 5"
FT   REPEAT          334..374
FT                   /note="WD 6"
FT   REPEAT          378..416
FT                   /note="WD 7"
FT   REGION          10..91
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   419 AA;  46959 MW;  45A1BA1925D75F37 CRC64;
     MEAENGEGQV QVHLKTKQEH YAVPDVPYAI DGSVSTTELN IFLNALLQSK GAEGVDFDFL
     VFDEYLRGRL CDHLREKAIS FEDAIDIEYV ERFPAPEPQD CLLHDDWVSA VKACGKWILT
     GCYDNTINIW TNKGKHKLTI PGHTAPIKAV DWISMDDENG RFVSTSQDQT AMLWQWNIAS
     NAVECVSVCK GHERGVDSVC VSPDAQRFAT GSWDTMLKIW SAGLDDTSEG TAKRVKESGV
     RTPKMTLQGH RESISAVQWM DATTLVTGSW DHTLKVWDLQ LEGIKTEIST NKSIFDASYS
     KLNRLIVTAS ADKNLRLYDA RTNQGSVVRN TYLGHNAWVQ TVMWSNTEEF LFVSGSYDTQ
     NKLWDCRSPK APLYDLLGHG EKVLDIDWSN PKYIVSGGAD NTVRVFKSGK ATIENMETK