ID   WDR12_DROWI             Reviewed;         423 AA.
AC   B4MU54;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GK23981;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH963852; EDW75643.1; -; Genomic_DNA.
DR   RefSeq; XP_002064657.1; XM_002064621.2.
DR   AlphaFoldDB; B4MU54; -.
DR   SMR; B4MU54; -.
DR   STRING; 7260.FBpp0253124; -.
DR   EnsemblMetazoa; FBtr0254632; FBpp0253124; FBgn0225943.
DR   GeneID; 6641752; -.
DR   KEGG; dwi:6641752; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; B4MU54; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B4MU54; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..423
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369565"
FT   REPEAT          105..142
FT                   /note="WD 1"
FT   REPEAT          144..186
FT                   /note="WD 2"
FT   REPEAT          193..232
FT                   /note="WD 3"
FT   REPEAT          253..291
FT                   /note="WD 4"
FT   REPEAT          293..332
FT                   /note="WD 5"
FT   REPEAT          338..378
FT                   /note="WD 6"
FT   REPEAT          382..420
FT                   /note="WD 7"
FT   REGION          10..93
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   423 AA;  47477 MW;  AC9B0E84FE36E81D CRC64;
     MDAENGEGQV QVHLKTKQEH YAVPDVPYAI DGTMTTVELN TFLNALLRNK SGDESAIDFD
     FLVFDEYLRG RLCDHLKEKA ISFEDAIEIE YVERFPAPQP QDCLLHDDWV SAVKVSGKWI
     LTGCYDNTLN IWTHKGKHIL TIPGHTAPIK AVDWISLDND IGRFVSSSQD QTVMLWQWNV
     DSNAVECVSI CKGHERGVDS ISVSPDATRF ATGSWDTMLK VWSAAEDDAG GDAASSKRPK
     ENGVRTPIMT LQGHRESISA VQWIDTSTLL TTSWDHTMKI WDLSLEGIKT EISTNKSIFD
     ASYSNLNRLI VTASADKNLR LYDPRTNQGS IVRNTYLGHN AWVQTVMWST TEEFLFVSGA
     YDNQNKLWDC RSPKAPLYDL LGHGEKVLDI DWSNPKYICS GGADNTVRVF KSRKAGVETM
     DDK