ID   WDR12_DROYA             Reviewed;         420 AA.
AC   B4P116; Q6XIB0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=GE13328;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 229-420.
RX   PubMed=14525923; DOI=10.1101/gr.1311003;
RA   Domazet-Loso T., Tautz D.;
RT   "An evolutionary analysis of orphan genes in Drosophila.";
RL   Genome Res. 13:2213-2219(2003).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CM000157; EDW87991.1; -; Genomic_DNA.
DR   EMBL; AY231921; AAR09944.1; -; mRNA.
DR   RefSeq; XP_002088279.1; XM_002088243.2.
DR   AlphaFoldDB; B4P116; -.
DR   SMR; B4P116; -.
DR   STRING; 7245.FBpp0258338; -.
DR   EnsemblMetazoa; FBtr0259846; FBpp0258338; FBgn0068268.
DR   GeneID; 6527185; -.
DR   KEGG; dya:Dyak_GE13328; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B4P116; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT   CHAIN           1..420
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369566"
FT   REPEAT          104..142
FT                   /note="WD 1"
FT   REPEAT          143..185
FT                   /note="WD 2"
FT   REPEAT          192..231
FT                   /note="WD 3"
FT   REPEAT          250..288
FT                   /note="WD 4"
FT   REPEAT          290..329
FT                   /note="WD 5"
FT   REPEAT          335..375
FT                   /note="WD 6"
FT   REPEAT          379..417
FT                   /note="WD 7"
FT   REGION          10..92
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   420 AA;  47125 MW;  5685B849E3C1A5CF CRC64;
     MDVENGEGQV QVHLKTKQEH YAVPDVPYAI DGTVTTVELN TFVNALLRQK DGSSDTDFDF
     LVFDEYLRGR LCDHLREKAI SFEDAIEIEY VERFPAPEPQ DCLLHDDWVS AVKASGKWIL
     SGCYDNTLNL WTNKGKHILT ISGHTAPIKA VDWISLDEET GRFVSTSQDQ TAMLWQWNVG
     SNSVECVSVC KGHERGVDSV SVSPDGLRFA TGSWDTMLKV WSAEVEDAVE GSSKRMKESG
     VRTPKITLQG HRESVSAVQW MDASTLLTGS WDHTLKVWDL SLEGIKTEIS TNKSIFDASY
     SKLNRLILTA SADKNLRLYD PRTNQGSVVR NTYLGHNAWV QTVMWSTTEE FLFVSGAYDN
     QNKLWDCRSP KAPLYDLLGH GEKVLDIDWS NPKYIVSGGV DNTVRVFKSR KALADDAETK