ID   WDR12_IXOSC             Reviewed;         425 AA.
AC   B7PY76;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=ISCW009002;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel;
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; DS818268; EEC11548.1; -; Genomic_DNA.
DR   RefSeq; XP_002402666.1; XM_002402622.1.
DR   AlphaFoldDB; B7PY76; -.
DR   SMR; B7PY76; -.
DR   STRING; 6945.B7PY76; -.
DR   KEGG; isc:IscW_ISCW009002; -.
DR   VEuPathDB; VectorBase:ISCI009002; -.
DR   VEuPathDB; VectorBase:ISCW009002; -.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; B7PY76; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B7PY76; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..425
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369567"
FT   REPEAT          105..142
FT                   /note="WD 1"
FT   REPEAT          145..187
FT                   /note="WD 2"
FT   REPEAT          194..233
FT                   /note="WD 3"
FT   REPEAT          265..303
FT                   /note="WD 4"
FT   REPEAT          305..344
FT                   /note="WD 5"
FT   REPEAT          350..390
FT                   /note="WD 6"
FT   REPEAT          394..425
FT                   /note="WD 7"
FT   REGION          7..93
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          227..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  47070 MW;  4150EEDBA7E6AC35 CRC64;
     MGETAQIQAK FFTKDERYSV PDTPFSIAGS TTPEQLSSLI NALLKESSAS PDQDEQPAFD
     FLINGELLRL TLEEHLETKE IPQETIVHLE YLEKCPPPSP VDSLIHDDWV SAVHASEAGI
     LSGCYDNTLH IWDTATGTRR LTIPGHLGPI KSVKWVAVAE PPCTFVSTSH DETAMLWQWD
     RRTNAVESVQ VCRGHARSVD CVDVSWNGAK FVTGSFDHML KVWSADPDST DTDHGQDGSE
     EGSRKKQKTV DGKAKTRVPV LTLAGHHEAV TGVQWTDEGE VATCSMDHTL RIWDVELGGM
     KSQLAGSKAF LGISYSRLNR QIVSASSDRH VRLWDPRTKD GTIVKCSYTS HAGWVSAVHW
     APNSDHQFIS GSYDTLMKLW DARSPKAPLY DMSGHEDKVL AVDWSLGKYM ISGGADNQLK
     IFEHK