ID   WDR12_MONBE             Reviewed;         447 AA.
AC   A9UP22;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=30764;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH991543; EDQ92799.1; -; Genomic_DNA.
DR   RefSeq; XP_001742561.1; XM_001742509.1.
DR   AlphaFoldDB; A9UP22; -.
DR   SMR; A9UP22; -.
DR   STRING; 81824.XP_001742561.1; -.
DR   EnsemblProtists; EDQ92799; EDQ92799; MONBRDRAFT_30764.
DR   GeneID; 5887770; -.
DR   KEGG; mbr:MONBRDRAFT_30764; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   InParanoid; A9UP22; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..447
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369570"
FT   REPEAT          107..147
FT                   /note="WD 1"
FT   REPEAT          148..191
FT                   /note="WD 2"
FT   REPEAT          195..234
FT                   /note="WD 3"
FT   REPEAT          262..300
FT                   /note="WD 4"
FT   REPEAT          304..344
FT                   /note="WD 5"
FT   REPEAT          350..398
FT                   /note="WD 6"
FT   REPEAT          414..447
FT                   /note="WD 7"
FT   REGION          11..92
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   447 AA;  48702 MW;  E7ADA99C299EAAD1 CRC64;
     MASADETGQE LRISLFTTLP KRYVVTSAPI AVPANLRRRG LSSLINSMLD LDPPKPFDFL
     IEHEYLRSSL LDHVLQSQKD GAEAIIKVEY TLAMPPPQPG PSMPHEDWVG GLASTSVNGQ
     EWLATASYDH HGRLWLPKRT ECERVLQGHT RPVLGVDFIT TDHSESVDVA TGGMDQAVRI
     WQHRETESRV LVGLGHRGTV QCVAAQPTGN IVASGSWDHE IFLWSCVPDA DDLDSAPGNK
     RRKVDSLYNE VQLKAPLGHL HGSGSVVHDM AWASVDTLYS VGGDHAVRQW DVEAGKLKMT
     QVGAKTGHGV AVHQGNAEHL TVATADVDGA ARLYDFRTAG GTSGTTVLRS FTGPAHAVAF
     NPTNAYQVAV CGDEAIVNLE MAYPIKIWDR RSTRMPLHNL RVPAAEVPRG TERVDSYRML
     ALTWTPSALF AGGASKRVHA FHTESVQ