ID   WDR12_NEMVE             Reviewed;         416 AA.
AC   A7RHG8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
DE   Flags: Fragment;
GN   ORFNames=v1g82024;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; DS469511; EDO48980.1; -; Genomic_DNA.
DR   RefSeq; XP_001641043.1; XM_001640993.1.
DR   AlphaFoldDB; A7RHG8; -.
DR   SMR; A7RHG8; -.
DR   STRING; 45351.EDO48980; -.
DR   EnsemblMetazoa; EDO48980; EDO48980; NEMVEDRAFT_v1g82024.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; A7RHG8; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; A7RHG8; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..>416
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369568"
FT   REPEAT          101..138
FT                   /note="WD 1"
FT   REPEAT          140..184
FT                   /note="WD 2"
FT   REPEAT          189..228
FT                   /note="WD 3"
FT   REPEAT          259..297
FT                   /note="WD 4"
FT   REPEAT          299..338
FT                   /note="WD 5"
FT   REPEAT          344..384
FT                   /note="WD 6"
FT   REPEAT          388..416
FT                   /note="WD 7"
FT   REGION          7..89
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          226..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         416
SQ   SEQUENCE   416 AA;  46022 MW;  2B204BECB137CBDB CRC64;
     MADVEQVQVR FFTKQKKYEI ADTPFSLSAN IGHGDLNDLI NGLLGAGNVG QSIQFDFLID
     SQYLQDTIQK HMKAKEISAE SVVEIEYLEK HPAPQPDNIL VHDDWVSSVS RCKNCIITGS
     YDNCVQIWDD QGSCLAKVKG HTSPVKDVEW VSKDEQKGVF LSSSQDQSIR VMEWSIGSGE
     ASCVHVCKGH TQSVDSISIN PSATKFCSGS WDKTLKLWSA VVNPEGGDEG ENGSLSKKQK
     TTGVKKKATT RTPLMTFTGH TQAVSSVVWM DRTTICSAGW DHCIRLWDAE SGVNKQTLTG
     SKVFCEIAYS ALNQCLASGS ADKYIRLWDH RAEDGQVVRG ILTSHQGWVS SVSWSPSNQF
     ELASASYDTT VKIWDTRSPY TPLYTLTGHQ DKVMCVRWSS SRHLMSGGTD NQLILY