WDR12_RAT
ID WDR12_RAT Reviewed; 423 AA.
AC P61480;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029};
DE AltName: Full=WD repeat-containing protein 12 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=Wdr12;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. The complex is held together by BOP1, which interacts with PES1
CC via its N-terminal domain and with WDR12 via a high-affinity
CC interaction between the seven-bladed beta-propeller domains of the 2
CC proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; BC063180; AAH63180.1; -; mRNA.
DR RefSeq; NP_955442.1; NM_199410.2.
DR RefSeq; XP_017452007.1; XM_017596518.1.
DR RefSeq; XP_017452008.1; XM_017596519.1.
DR RefSeq; XP_017452009.1; XM_017596520.1.
DR RefSeq; XP_017452010.1; XM_017596521.1.
DR AlphaFoldDB; P61480; -.
DR SMR; P61480; -.
DR STRING; 10116.ENSRNOP00000023463; -.
DR iPTMnet; P61480; -.
DR PhosphoSitePlus; P61480; -.
DR jPOST; P61480; -.
DR PaxDb; P61480; -.
DR PRIDE; P61480; -.
DR Ensembl; ENSRNOT00000023463; ENSRNOP00000023463; ENSRNOG00000017340.
DR GeneID; 363237; -.
DR KEGG; rno:363237; -.
DR UCSC; RGD:735072; rat.
DR CTD; 55759; -.
DR RGD; 735072; Wdr12.
DR eggNOG; KOG0313; Eukaryota.
DR GeneTree; ENSGT00930000150950; -.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; P61480; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR PhylomeDB; P61480; -.
DR TreeFam; TF313023; -.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:P61480; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000017340; Expressed in testis and 20 other tissues.
DR Genevisible; P61480; RN.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; ISS:UniProtKB.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Ribosome biogenesis; rRNA processing; Ubl conjugation; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9GZL7"
FT CHAIN 2..423
FT /note="Ribosome biogenesis protein WDR12"
FT /id="PRO_0000051360"
FT REPEAT 99..137
FT /note="WD 1"
FT REPEAT 138..180
FT /note="WD 2"
FT REPEAT 187..226
FT /note="WD 3"
FT REPEAT 255..293
FT /note="WD 4"
FT REPEAT 295..334
FT /note="WD 5"
FT REPEAT 340..380
FT /note="WD 6"
FT REPEAT 384..422
FT /note="WD 7"
FT REGION 4..87
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 98..423
FT /note="Sufficient for nucleolar localization"
FT /evidence="ECO:0000250"
FT REGION 222..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9GZL7"
FT MOD_RES 415
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9GZL7"
FT CROSSLNK 239
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q9GZL7"
SQ SEQUENCE 423 AA; 47563 MW; 652E41B6E5AEC446 CRC64;
MAQLQARFYT ENKKYAVDDV PFSIPATSEV ADLSNIINKL LETKNELHKH VEFDFLIKGQ
FLRMPLVKHM ELEDISSEEV VELEYVEKYT APQPEQCMFH DDWISSIKGA EEWILSGSYD
KTSRIWSLEG KSIMTIVGHT DVVKDVAWVK KDSLSCLLLT ASMDQTILLW EWNIERNKVK
ALHCCRGHAG SVDAIAVDSS GTKFCSGSWD KMLKIWSTVP TDEEDEIQEP TNRPRKKQKT
EQLGLTRTPL VTLSGHTEAI SSVLWSDADE VCSASWDHTV RVWDVESGGL KSTLTGNKVF
NCISYSPLCK RLASGSTDRH IRLWDPRTKD GSLVSLSLTS HTGWVTSVKW SPTHDQQLIS
GSLDNMVKLW DTRSCKAPLY DLAAHEDKVL SVDWTDTGLL LSGGADNKLY SYRYSPTTSH
VGA
