ID   WDR12_SALSA             Reviewed;         423 AA.
AC   B5DG67;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Ribosome biogenesis protein wdr12 {ECO:0000255|HAMAP-Rule:MF_03029};
DE   AltName: Full=WD repeat-containing protein 12 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=wdr12;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=White muscle;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Component of the PeBoW complex, which is required for
CC       maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and
CC       wdr12. The complex is held together by bop1, which interacts with pes1
CC       via its N-terminal domain and with wdr12 via a high-affinity
CC       interaction between the seven-bladed beta-propeller domains of the 2
CC       proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC       Interacts (via UBL domain) with mdn1 (via VWFA/MIDAS domain).
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; BT043626; ACH70741.1; -; mRNA.
DR   RefSeq; XP_014006656.1; XM_014151181.1.
DR   AlphaFoldDB; B5DG67; -.
DR   SMR; B5DG67; -.
DR   STRING; 8030.ENSSSAP00000016985; -.
DR   GeneID; 106575042; -.
DR   KEGG; sasa:106575042; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa16.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; ISS:UniProtKB.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..423
FT                   /note="Ribosome biogenesis protein wdr12"
FT                   /id="PRO_0000369549"
FT   REPEAT          99..136
FT                   /note="WD 1"
FT   REPEAT          138..180
FT                   /note="WD 2"
FT   REPEAT          187..226
FT                   /note="WD 3"
FT   REPEAT          255..293
FT                   /note="WD 4"
FT   REPEAT          295..334
FT                   /note="WD 5"
FT   REPEAT          340..380
FT                   /note="WD 6"
FT   REPEAT          384..422
FT                   /note="WD 7"
FT   REGION          4..87
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          221..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47528 MW;  F955DE861C31E25A CRC64;
     MSQLQTRFFT DNKKYSVDDV PFSIPAASEV QELSNVINKL LEAKNGSRSQ IEFDFLVQGQ
     FLRTSLSNHM EAEGISTEDV VEIEYVERFT APQPEECMMH DDWISSVEAD SEWILTGSYD
     KTAKIWSLEG KAVMTVAGHT DVVKDVAWVK RDGLTSLLLT ASLDQTILLW EWNSERNKLK
     ARHCCRGHAG SVDTIATDPT RTKFCSGSWD KMLKIWSAVA TEEEEEEEEP PSRPRKKQKT
     EQLGLTRTPL MTLSGHNEAV SSVLWLDSEE ICSASWDHTI RLWDAETGSV KTSLTGSKVF
     NHISYSPLCR RLASGSTDRH VRLWDPRSKD GSLVLLSLTS HSGWVTAVKW APSHEHQLVS
     GSLDNLVKLW DTRSCKAPLY DVSAHEDKVL CVDWTDSRLM LSGGADNKLY TYRYTACETD
     AGA