ID   WDR12_TRIAD             Reviewed;         432 AA.
AC   B3RQN1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog {ECO:0000255|HAMAP-Rule:MF_03029};
GN   ORFNames=TRIADDRAFT_55049;
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax.
OX   NCBI_TaxID=10228;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999;
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV26724.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS985243; EDV26724.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002110720.1; XM_002110684.1.
DR   AlphaFoldDB; B3RQN1; -.
DR   SMR; B3RQN1; -.
DR   STRING; 10228.TriadP55049; -.
DR   PRIDE; B3RQN1; -.
DR   GeneID; 6751933; -.
DR   KEGG; tad:TRIADDRAFT_55049; -.
DR   CTD; 6751933; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   InParanoid; B3RQN1; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; B3RQN1; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..432
FT                   /note="Ribosome biogenesis protein WDR12 homolog"
FT                   /id="PRO_0000369569"
FT   REPEAT          109..146
FT                   /note="WD 1"
FT   REPEAT          148..190
FT                   /note="WD 2"
FT   REPEAT          197..236
FT                   /note="WD 3"
FT   REPEAT          265..303
FT                   /note="WD 4"
FT   REPEAT          305..345
FT                   /note="WD 5"
FT   REPEAT          352..392
FT                   /note="WD 6"
FT   REPEAT          396..432
FT                   /note="WD 7"
FT   REGION          13..97
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   432 AA;  48233 MW;  7083D3832B81C8A9 CRC64;
     MELENDKTSS KQLQIRLVAL NKRFDTSGNL LSLPSRFGCD ELSETVHTLL SANDIEIPAS
     VQFDFAINND LLRDSLEGYV TSKNLSTESV IEVVYFQKEP PPDFLNTILH SDWIKSVRSK
     DDCILAGSLD GTARIWNMAG EEYAIFKGHE SYVNGVEWIS KDNNHATIVT ASQDGTLRLW
     EWAIGTKSVE CLCECKGHTQ AVNAVTVNQS KTKICSVSSD KMIKIWSTDC SRKDDDTTHP
     IHKKMKTNQG LQKAVDKLPD ITLSGHTDGI DAVVWPKEAE IITAGWDHRI KIWDTEVGVN
     KSDINVNKVV KGITCSPFQD LIAAGSFDEG IIRLYDPRVV GDQTVLKLTL KSHKNIVSSL
     CWSTTDEQQL VSGSFDNTVK LWDIRCNLAP LYSIEGHEDK VLAVDWSEPQ YIVSGGADNR
     IQIYQREVAQ RS