ID   WDR12_XENTR             Reviewed;         423 AA.
AC   Q5BJ90;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ribosome biogenesis protein wdr12 {ECO:0000255|HAMAP-Rule:MF_03029};
DE   AltName: Full=WD repeat-containing protein 12 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=wdr12;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the PeBoW complex, which is required for
CC       maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and
CC       wdr12. The complex is held together by bop1, which interacts with pes1
CC       via its N-terminal domain and with wdr12 via a high-affinity
CC       interaction between the seven-bladed beta-propeller domains of the 2
CC       proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC       Interacts (via UBL domain) with mdn1 (via VWFA/MIDAS domain).
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; BC091577; AAH91577.1; -; mRNA.
DR   RefSeq; NP_001025628.1; NM_001030457.1.
DR   AlphaFoldDB; Q5BJ90; -.
DR   SMR; Q5BJ90; -.
DR   STRING; 8364.ENSXETP00000047773; -.
DR   PaxDb; Q5BJ90; -.
DR   PRIDE; Q5BJ90; -.
DR   Ensembl; ENSXETT00000047773; ENSXETP00000047773; ENSXETG00000022077.
DR   GeneID; 595016; -.
DR   KEGG; xtr:595016; -.
DR   CTD; 55759; -.
DR   Xenbase; XB-GENE-945426; wdr12.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; Q5BJ90; -.
DR   OMA; PKPLHDI; -.
DR   OrthoDB; 1540178at2759; -.
DR   PhylomeDB; Q5BJ90; -.
DR   TreeFam; TF313023; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022077; Expressed in neurula embryo and 14 other tissues.
DR   ExpressionAtlas; Q5BJ90; differential.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; ISS:UniProtKB.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..423
FT                   /note="Ribosome biogenesis protein wdr12"
FT                   /id="PRO_0000354082"
FT   REPEAT          99..137
FT                   /note="WD 1"
FT   REPEAT          138..180
FT                   /note="WD 2"
FT   REPEAT          187..226
FT                   /note="WD 3"
FT   REPEAT          255..293
FT                   /note="WD 4"
FT   REPEAT          295..334
FT                   /note="WD 5"
FT   REPEAT          340..380
FT                   /note="WD 6"
FT   REPEAT          384..422
FT                   /note="WD 7"
FT   REGION          4..87
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   423 AA;  47465 MW;  5367766C11DB39D2 CRC64;
     MAQIQARFFT EEEKYKVDDV PFSIPATSEI VDLSNLINKL LETKNGDHKP VEFDFLVKSQ
     FLRMPLIKHM EAEGISTEVV VEIEYVEKIT APQPEECMMH DDWVSSIAGT EEWILTGSYD
     KTCRIWSLEG KTIMTITGHT EAVKDVTWVK KDSLSCLLLS ASIDQTIQLW EWNTERNKIK
     ALHCCRGHAG SVDSIAVDAS RTKFCSGSWD KMLKIWSAVP SEEEDEYEET SDRPRKKQKT
     EKMGLTRIPI VTLSGHSEAV SSVLWSDVDE ICSASWDHNI KIWDVETGTV KSTLAGNKVF
     NCISYSPLSQ RLASGSTDRH IRLWDPRSKD GSLVLCSLTS HTGWVTSVKW SPSHEQQLVS
     GSLDKLVKLW DTRSCKAPLY DLAAHSDKVL SVDWTDAGLI LSGGSDNKLY SYRYTASLSD
     VGA