WDR13_HUMAN
ID WDR13_HUMAN Reviewed; 485 AA.
AC Q9H1Z4; Q06DW8; Q06DX0; Q06DX1; Q9BUL7; Q9NWW4;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=WD repeat-containing protein 13;
GN Name=WDR13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR
RP LOCATION, ALTERNATIVE SPLICING, AND VARIANT ARG-325.
RC TISSUE=Brain, Stomach, and Testis;
RX PubMed=12659815; DOI=10.1016/s0888-7543(02)00036-8;
RA Singh B.N., Suresh A., UmaPrasad G., Subramanian S., Sultana M., Goel S.,
RA Kumar S., Singh L.;
RT "A highly conserved human gene encoding a novel member of WD-repeat family
RT of proteins (WDR13).";
RL Genomics 81:315-328(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-325.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-325.
RC TISSUE=Colon, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-485 (ISOFORM 1/2), AND
RP VARIANT ARG-325.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 2), AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-74 AND SER-79, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-114, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12659815}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H1Z4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H1Z4-2; Sequence=VSP_054010;
CC -!- TISSUE SPECIFICITY: Widely expressed.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91261.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF329819; AAG47845.3; -; mRNA.
DR EMBL; DQ907252; ABI93266.1; -; mRNA.
DR EMBL; DQ907253; ABI93267.1; -; mRNA.
DR EMBL; DQ907255; ABI93269.1; -; mRNA.
DR EMBL; AF149817; AAK13247.1; -; Genomic_DNA.
DR EMBL; AC115618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471224; EAW50760.1; -; Genomic_DNA.
DR EMBL; BC002507; AAH02507.2; -; mRNA.
DR EMBL; BC080579; AAH80579.1; -; mRNA.
DR EMBL; AK000570; BAA91261.1; ALT_INIT; mRNA.
DR RefSeq; NP_001159898.1; NM_001166426.2.
DR RefSeq; NP_001334146.1; NM_001347217.1.
DR RefSeq; NP_001334148.1; NM_001347219.1.
DR RefSeq; NP_060353.2; NM_017883.5.
DR RefSeq; XP_011542249.1; XM_011543947.2.
DR AlphaFoldDB; Q9H1Z4; -.
DR SMR; Q9H1Z4; -.
DR BioGRID; 122259; 13.
DR IntAct; Q9H1Z4; 6.
DR STRING; 9606.ENSP00000365919; -.
DR GlyGen; Q9H1Z4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H1Z4; -.
DR PhosphoSitePlus; Q9H1Z4; -.
DR BioMuta; WDR13; -.
DR DMDM; 296453034; -.
DR EPD; Q9H1Z4; -.
DR jPOST; Q9H1Z4; -.
DR MassIVE; Q9H1Z4; -.
DR MaxQB; Q9H1Z4; -.
DR PaxDb; Q9H1Z4; -.
DR PeptideAtlas; Q9H1Z4; -.
DR PRIDE; Q9H1Z4; -.
DR ProteomicsDB; 80460; -. [Q9H1Z4-1]
DR Antibodypedia; 366; 65 antibodies from 24 providers.
DR DNASU; 64743; -.
DR Ensembl; ENST00000218056.9; ENSP00000218056.5; ENSG00000101940.18.
DR Ensembl; ENST00000376729.10; ENSP00000365919.5; ENSG00000101940.18.
DR GeneID; 64743; -.
DR KEGG; hsa:64743; -.
DR UCSC; uc004dkj.3; human. [Q9H1Z4-1]
DR CTD; 64743; -.
DR DisGeNET; 64743; -.
DR GeneCards; WDR13; -.
DR HGNC; HGNC:14352; WDR13.
DR HPA; ENSG00000101940; Low tissue specificity.
DR MIM; 300512; gene.
DR neXtProt; NX_Q9H1Z4; -.
DR PharmGKB; PA37876; -.
DR VEuPathDB; HostDB:ENSG00000101940; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_026276_2_0_1; -.
DR InParanoid; Q9H1Z4; -.
DR OrthoDB; 673903at2759; -.
DR PhylomeDB; Q9H1Z4; -.
DR TreeFam; TF329058; -.
DR PathwayCommons; Q9H1Z4; -.
DR SignaLink; Q9H1Z4; -.
DR BioGRID-ORCS; 64743; 8 hits in 706 CRISPR screens.
DR ChiTaRS; WDR13; human.
DR GenomeRNAi; 64743; -.
DR Pharos; Q9H1Z4; Tbio.
DR PRO; PR:Q9H1Z4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9H1Z4; protein.
DR Bgee; ENSG00000101940; Expressed in body of pancreas and 192 other tissues.
DR ExpressionAtlas; Q9H1Z4; baseline and differential.
DR Genevisible; Q9H1Z4; HS.
DR GO; GO:0034451; C:centriolar satellite; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:1904691; P:negative regulation of type B pancreatic cell proliferation; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..485
FT /note="WD repeat-containing protein 13"
FT /id="PRO_0000051361"
FT REPEAT 162..202
FT /note="WD 1"
FT REPEAT 208..246
FT /note="WD 2"
FT REPEAT 250..290
FT /note="WD 3"
FT REPEAT 295..335
FT /note="WD 4"
FT REPEAT 341..389
FT /note="WD 5"
FT REPEAT 394..438
FT /note="WD 6"
FT REPEAT 444..482
FT /note="WD 7"
FT MOD_RES 70
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 79
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 114
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q91V09"
FT MOD_RES 114
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 1..92
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12659815"
FT /id="VSP_054010"
FT VARIANT 325
FT /note="H -> R (in dbSNP:rs235842)"
FT /evidence="ECO:0000269|PubMed:12659815,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.3"
FT /id="VAR_060284"
FT CONFLICT 353
FT /note="P -> L (in Ref. 4; BAA91261)"
FT /evidence="ECO:0000305"
FT MOD_RES Q9H1Z4-2:1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 485 AA; 53696 MW; 9F2CC02B1B2ED1D6 CRC64;
MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL RRQYLRLRGQ
LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP RALGARGHRR SVSRGSYQLQ
AQMNRAVYED RPPGSVVPTS AAEASRAMAG DTSLSENYAF AGMYHVFDQH VDEAVPRVRF
ANDDRHRLAC CSLDGSISLC QLVPAPPTVL RVLRGHTRGV SDFAWSLSND ILVSTSLDAT
MRIWASEDGR CIREIPDPDS AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS
SKLTGRVLAL SFDAPGRLLW AGDDHGSVFS FLFDMATGKL TKAKRLVVHE GSPVTSISAR
SWVSREARDP SLLINACLNK LLLYRVVDNE GTLQLKRSFP IEQSSHPVRS IFCPLMSFRQ
GACVVTGSED MCVHFFDVER AAKAAVNKLQ GHSAPVLDVS FNCDESLLAS SDASGMVIVW
RREQK
