WDR13_MOUSE
ID WDR13_MOUSE Reviewed; 485 AA.
AC Q91V09;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=WD repeat-containing protein 13;
GN Name=Wdr13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129, and CD-1; TISSUE=Testis;
RA Shah V., Singh L., Kumar S.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 295-302, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-114, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AF353243; AAK38600.1; -; mRNA.
DR EMBL; AF353244; AAK38601.1; -; Genomic_DNA.
DR CCDS; CCDS29986.1; -.
DR RefSeq; NP_080413.2; NM_026137.5.
DR RefSeq; XP_006527766.1; XM_006527703.3.
DR AlphaFoldDB; Q91V09; -.
DR SMR; Q91V09; -.
DR BioGRID; 216023; 2.
DR STRING; 10090.ENSMUSP00000033506; -.
DR iPTMnet; Q91V09; -.
DR PhosphoSitePlus; Q91V09; -.
DR EPD; Q91V09; -.
DR MaxQB; Q91V09; -.
DR PaxDb; Q91V09; -.
DR PRIDE; Q91V09; -.
DR ProteomicsDB; 297636; -.
DR Antibodypedia; 366; 65 antibodies from 24 providers.
DR DNASU; 73447; -.
DR Ensembl; ENSMUST00000033506; ENSMUSP00000033506; ENSMUSG00000031166.
DR Ensembl; ENSMUST00000115623; ENSMUSP00000111286; ENSMUSG00000031166.
DR GeneID; 73447; -.
DR KEGG; mmu:73447; -.
DR UCSC; uc009snu.3; mouse.
DR CTD; 64743; -.
DR MGI; MGI:1914661; Wdr13.
DR VEuPathDB; HostDB:ENSMUSG00000031166; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00940000153634; -.
DR HOGENOM; CLU_026276_2_0_1; -.
DR InParanoid; Q91V09; -.
DR OMA; MLKFANN; -.
DR OrthoDB; 673903at2759; -.
DR PhylomeDB; Q91V09; -.
DR TreeFam; TF329058; -.
DR BioGRID-ORCS; 73447; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Wdr13; mouse.
DR PRO; PR:Q91V09; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q91V09; protein.
DR Bgee; ENSMUSG00000031166; Expressed in saccule of membranous labyrinth and 261 other tissues.
DR ExpressionAtlas; Q91V09; baseline and differential.
DR Genevisible; Q91V09; MM.
DR GO; GO:0034451; C:centriolar satellite; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IDA:MGI.
DR GO; GO:1904691; P:negative regulation of type B pancreatic cell proliferation; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..485
FT /note="WD repeat-containing protein 13"
FT /id="PRO_0000051362"
FT REPEAT 170..210
FT /note="WD 1"
FT REPEAT 215..254
FT /note="WD 2"
FT REPEAT 302..341
FT /note="WD 3"
FT REPEAT 406..446
FT /note="WD 4"
FT REPEAT 451..484
FT /note="WD 5"
FT MOD_RES 70
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H1Z4"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H1Z4"
FT MOD_RES 79
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H1Z4"
FT MOD_RES 114
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 114
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 485 AA; 53664 MW; E42F6101B7849431 CRC64;
MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL RRQYLRLRGQ
LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP RALGARGHRR SVSRGSYQLQ
AQMNRAVYED RPPGSVVPTS VAEASRAMAG DTSLSENYAF AGMYHVFDQH VDEAVPRVRF
ANDDRHRLAC CSLDGSISLC QLVPAPPTVL HVLRGHTRGV SDFAWSLSND ILVSTSLDAT
MRIWASEDGR CIREIPDPDG AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS
SKLTGRVLAL SFDAPGRLLW AGDDRGSVFS FLFDMATGKL TKAKRLVVHE GSPVTSISAR
SWVSREARDP SLLINACLNK LLLYRVVDNE GALQLKRSFP IEQSSHPVRS IFCPLMSFRQ
GACVVTGSED MCVHFFDVER AAKAAVNKLQ GHSAPVLDVS FNCDESLLAS SDASGMVIVW
RREQK
