ID   WDR18_BOVIN             Reviewed;         432 AA.
AC   Q3SZD4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=WD repeat-containing protein 18;
GN   Name=WDR18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC       CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC       methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC       transactivation of ZNF148 target genes (By similarity). Component of
CC       the PELP1 complex involved in the nucleolar steps of 28S rRNA
CC       maturation and the subsequent nucleoplasmic transit of the pre-60S
CC       ribosomal subunit (By similarity). May play a role during development
CC       (By similarity). {ECO:0000250|UniProtKB:Q68EI0,
CC       ECO:0000250|UniProtKB:Q9BV38}.
CC   -!- SUBUNIT: Component of the 5FMC complex, at least composed of PELP1,
CC       LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated
CC       CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex,
CC       composed of at least PELP1, TEX10 and WDR18. The complex interacts with
CC       pre-60S ribosome particles. {ECO:0000250|UniProtKB:Q9BV38}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9BV38}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q4VBE8}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q4VBE8}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A0A1L8HX76}. Note=Mainly found in the
CC       nucleoplasm, with low levels detected in the cytoplasmic and chromatin
CC       fractions. {ECO:0000250|UniProtKB:Q4VBE8}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR   EMBL; BC102946; AAI02947.1; -; mRNA.
DR   RefSeq; NP_001029760.1; NM_001034588.1.
DR   AlphaFoldDB; Q3SZD4; -.
DR   SMR; Q3SZD4; -.
DR   STRING; 9913.ENSBTAP00000003156; -.
DR   PaxDb; Q3SZD4; -.
DR   PRIDE; Q3SZD4; -.
DR   GeneID; 533356; -.
DR   KEGG; bta:533356; -.
DR   CTD; 57418; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_0_0_1; -.
DR   InParanoid; Q3SZD4; -.
DR   OrthoDB; 747023at2759; -.
DR   TreeFam; TF313046; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   InterPro; IPR026987; Wdr18_C_dom.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   Pfam; PF00400; WD40; 2.
DR   Pfam; PF14077; WD40_alt; 1.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..432
FT                   /note="WD repeat-containing protein 18"
FT                   /id="PRO_0000244453"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          78..116
FT                   /note="WD 2"
FT   REPEAT          119..158
FT                   /note="WD 3"
FT   REPEAT          170..211
FT                   /note="WD 4"
FT   REPEAT          213..257
FT                   /note="WD 5"
FT   REPEAT          267..306
FT                   /note="WD 6"
SQ   SEQUENCE   432 AA;  47611 MW;  8E1BBB3810AF01D3 CRC64;
     MAAPMEVAVC TDSAAQLWSC VVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQLGKN
     YICAWELQRK DQLQQKIMCP GPVTCLTTSP NGLYVLAGIS ENIYLWEVST GNLLVILSRH
     YQDVSCLQFT GDSSHFISGG KDCLVLAWSL CSVLQADPSR TPAPRHVWSR HTLPITDLHC
     GFGGPLARVA TASLDQTVKL WEVSSGELLL SVLFDVGILA VTMDLAEHYM FCGGSDGSIF
     QVDLCTWPGQ REKSFQPEQE HGKVFRGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS
     QQCLRTVTLK GPVTNACIML APVSMLSSDF RPGLPLPHFN KHLLGAEHGD EPHRGGLMLR
     LGLHQQGSEP SYLERVEQLQ AVMSSTLEKN VLGGQDQLRI RVTELEDEVR NLRKINRDLF
     DFSTRIITHP TK