ID   WDR18_RAT               Reviewed;         431 AA.
AC   Q499N3;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=WD repeat-containing protein 18;
GN   Name=Wdr18;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC       CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC       methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC       transactivation of ZNF148 target genes (By similarity). Component of
CC       the PELP1 complex involved in the nucleolar steps of 28S rRNA
CC       maturation and the subsequent nucleoplasmic transit of the pre-60S
CC       ribosomal subunit (By similarity). May play a role during development
CC       (By similarity). {ECO:0000250|UniProtKB:Q68EI0,
CC       ECO:0000250|UniProtKB:Q9BV38}.
CC   -!- SUBUNIT: Component of the 5FMC complex, at least composed of PELP1,
CC       LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated
CC       CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex,
CC       composed of at least PELP1, TEX10 and WDR18. The complex interacts with
CC       pre-60S ribosome particles. {ECO:0000250|UniProtKB:Q9BV38}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9BV38}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q4VBE8}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q4VBE8}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A0A1L8HX76}. Note=Mainly found in the
CC       nucleoplasm, with low levels detected in the cytoplasmic and chromatin
CC       fractions. {ECO:0000250|UniProtKB:Q4VBE8}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC099828; AAH99828.1; -; mRNA.
DR   RefSeq; NP_001034116.1; NM_001039027.1.
DR   AlphaFoldDB; Q499N3; -.
DR   SMR; Q499N3; -.
DR   STRING; 10116.ENSRNOP00000016733; -.
DR   PhosphoSitePlus; Q499N3; -.
DR   jPOST; Q499N3; -.
DR   PaxDb; Q499N3; -.
DR   PRIDE; Q499N3; -.
DR   GeneID; 314617; -.
DR   KEGG; rno:314617; -.
DR   UCSC; RGD:1310646; rat.
DR   CTD; 57418; -.
DR   RGD; 1310646; Wdr18.
DR   eggNOG; KOG0646; Eukaryota.
DR   InParanoid; Q499N3; -.
DR   OrthoDB; 747023at2759; -.
DR   PhylomeDB; Q499N3; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q499N3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   InterPro; IPR026987; Wdr18_C_dom.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   Pfam; PF00400; WD40; 2.
DR   Pfam; PF14077; WD40_alt; 1.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..431
FT                   /note="WD repeat-containing protein 18"
FT                   /id="PRO_0000233182"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          78..116
FT                   /note="WD 2"
FT   REPEAT          119..158
FT                   /note="WD 3"
FT   REPEAT          170..211
FT                   /note="WD 4"
FT   REPEAT          213..257
FT                   /note="WD 5"
FT   REPEAT          267..306
FT                   /note="WD 6"
SQ   SEQUENCE   431 AA;  47225 MW;  D354B01EF33EAD76 CRC64;
     MAAPMEVVVC TDSAAPLWSC MVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQQGKN
     YICAWELQRK DQLQQKIMCP GPVTCLTTAP NGLYVLAGIA ESIYLWEVST GNLLVILSRH
     YQDVSCLKFT GDGSHFVSAG KDCLVLAWSL CSVLQADPSR ILAPRHVWSQ HTLPITDLHC
     GFGGPMARVA TASLDQTMKL WAISSGDLLL SVLFDMGITS VTMDLAEHYI FCGGSDGSIF
     QVDLCSRPGP REQSFQPEQN TGKVFKGHRN QVTCLSVSTD GSILLSGSHD ESVRLWDVKS
     KQCVRTVPLK GPVTNAAITL APPSMLNPEF RPSLPLPHFN KHLLGAEHGD EAQGGGLRLQ
     LGLHLQGKEP SYLERLEQLQ AALSGYLEKN MLGSQMLPVR VFELEEEVRS LRKINRDLFD
     FSTRIITRPS K