WDR18_XENLA
ID WDR18_XENLA Reviewed; 428 AA.
AC A0A1L8HX76;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=WD repeat-containing protein 18;
GN Name=wdr18 {ECO:0000312|Xenbase:XB-GENE-17343645};
GN ORFNames=XELAEV_18006255mg {ECO:0000312|EMBL:OCU00478.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000312|EMBL:OCU00478.1};
RN [1] {ECO:0000312|Proteomes:UP000186698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J {ECO:0000312|Proteomes:UP000186698};
RX PubMed=27762356; DOI=10.1038/nature19840;
RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL Nature 538:336-343(2016).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=33263282; DOI=10.7554/elife.58662;
RA Lee C., Cox R.M., Papoulas O., Horani A., Drew K., Devitt C.C., Brody S.L.,
RA Marcotte E.M., Wallingford J.B.;
RT "Functional partitioning of a liquid-like organelle during assembly of
RT axonemal dyneins.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC transactivation of ZNF148 target genes. Component of the PELP1 complex
CC involved in the nucleolar steps of 28S rRNA maturation and the
CC subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By
CC similarity). May play a role during development (By similarity).
CC {ECO:0000250|UniProtKB:Q68EI0, ECO:0000250|UniProtKB:Q9BV38}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9BV38}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q4VBE8}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q4VBE8}. Dynein axonemal particle
CC {ECO:0000269|PubMed:33263282}. Note=Mainly found in the nucleoplasm,
CC with low levels detected in the cytoplasmic and chromatin fractions.
CC {ECO:0000250|UniProtKB:Q4VBE8}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR EMBL; CM004466; OCU00478.1; -; Genomic_DNA.
DR RefSeq; XP_018080674.1; XM_018225185.1.
DR AlphaFoldDB; A0A1L8HX76; -.
DR SMR; A0A1L8HX76; -.
DR STRING; 8355.A0A1L8HX76; -.
DR GeneID; 733228; -.
DR KEGG; xla:733228; -.
DR CTD; 733228; -.
DR Xenbase; XB-GENE-17343645; wdr18.L.
DR OMA; YIWIIAT; -.
DR OrthoDB; 747023at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 733228; Expressed in neurula embryo and 19 other tissues.
DR GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR InterPro; IPR026987; Wdr18_C_dom.
DR PANTHER; PTHR18763; PTHR18763; 1.
DR Pfam; PF00400; WD40; 2.
DR Pfam; PF14077; WD40_alt; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Developmental protein; Nucleus; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..428
FT /note="WD repeat-containing protein 18"
FT /id="PRO_0000452448"
FT REPEAT 36..75
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 78..118
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 119..158
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 170..211
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 213..252
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 265..304
FT /note="WD 6"
FT /evidence="ECO:0000255"
SQ SEQUENCE 428 AA; 46903 MW; 2AB8AA4DF4EE7DB0 CRC64;
MAAPLELVLS ADAAGQVANC TVWEPVTGSV LLTYRGGNTS HRGLAVLGGQ YLLGGQLGKN
YINVWELQRR DQLQQKIVCP GPVNCLSASP NGLYLVAGIA ESIYLWEVST GHLLAILNSH
YQDVTCLTFT DDSSHIISGA KDSLVLVWGL YSVLQVETSR GPEPRYVWSR HSLPITDVQC
GIGGPQARVA TSSLDQTIKL WDICSGDLLV SVLFDVRITS VAFDPAEYHL FCGGSDGVIY
QVDLYTTPEQ RERPFHPEQE MVFKGHRNQV TCLSVSLDGS MLISGSHDET VCVWDIQSKQ
SLRSVPHRGP VTNVFIIAAP SNMLRAESKP SFPLPHFSKH LQGAEGCEGP ESGGVILRLG
KQQGSKENTY LQRADQLQSL LGESEGKNLS GLVEQLRSRT SELEEELNVV RKINKDLFDF
SARIITKQ
