WDR1A_XENLA
ID WDR1A_XENLA Reviewed; 607 AA.
AC Q9W7F2; Q6DEC6;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=WD repeat-containing protein 1-A;
DE AltName: Full=Actin-interacting protein 1-A;
DE Short=xAIP1-A;
GN Name=wdr1-a; Synonyms=aip1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=10212149; DOI=10.1242/jcs.112.10.1553;
RA Okada K., Obinata T., Abe H.;
RT "XAIP1: a Xenopus homologue of yeast actin interacting protein 1 (AIP1),
RT which induces disassembly of actin filaments cooperatively with ADF/cofilin
RT family proteins.";
RL J. Cell Sci. 112:1553-1565(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=12055192; DOI=10.1074/jbc.m203111200;
RA Okada K., Blanchoin L., Abe H., Chen H., Pollard T.D., Bamburg J.R.;
RT "Xenopus actin-interacting protein 1 (XAip1) enhances cofilin fragmentation
RT of filaments by capping filament ends.";
RL J. Biol. Chem. 277:43011-43016(2002).
CC -!- FUNCTION: Induces disassembly of actin filaments in conjunction with
CC ADF/cofilin family proteins. Doesn't sever actin filaments alone, but
CC caps the barbed ends of filaments severed by cofilin, which blocks
CC annealing and depolymerization and allows more extensive severing by
CC cofilin. {ECO:0000269|PubMed:10212149, ECO:0000269|PubMed:12055192}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10212149}.
CC Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10212149}. Nucleus
CC {ECO:0000269|PubMed:10212149}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically with
CC expression levels remaining constant throughout development.
CC {ECO:0000269|PubMed:10212149}.
CC -!- SIMILARITY: Belongs to the WD repeat AIP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD22062.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF124140; AAD22062.1; ALT_FRAME; mRNA.
DR EMBL; BC041232; AAH41232.1; -; mRNA.
DR EMBL; BC077202; AAH77202.1; -; mRNA.
DR RefSeq; NP_001081923.1; NM_001088454.1.
DR AlphaFoldDB; Q9W7F2; -.
DR SMR; Q9W7F2; -.
DR DNASU; 398123; -.
DR GeneID; 398123; -.
DR KEGG; xla:398123; -.
DR CTD; 398123; -.
DR Xenbase; XB-GENE-6251934; wdr1.L.
DR OMA; HSSHREH; -.
DR OrthoDB; 325552at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR GO; GO:0005884; C:actin filament; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; IDA:UniProtKB.
DR GO; GO:0030043; P:actin filament fragmentation; IDA:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011045; N2O_reductase_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50974; SSF50974; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..607
FT /note="WD repeat-containing protein 1-A"
FT /id="PRO_0000051344"
FT REPEAT 4..45
FT /note="WD 1"
FT REPEAT 48..87
FT /note="WD 2"
FT REPEAT 93..135
FT /note="WD 3"
FT REPEAT 138..176
FT /note="WD 4"
FT REPEAT 180..218
FT /note="WD 5"
FT REPEAT 224..263
FT /note="WD 6"
FT REPEAT 270..306
FT /note="WD 7"
FT REPEAT 311..351
FT /note="WD 8"
FT REPEAT 358..408
FT /note="WD 9"
FT REPEAT 432..474
FT /note="WD 10"
FT REPEAT 480..518
FT /note="WD 11"
FT REPEAT 523..561
FT /note="WD 12"
FT REPEAT 566..604
FT /note="WD 13"
FT CONFLICT 553
FT /note="D -> G (in Ref. 1; AAD22062)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 607 AA; 66163 MW; E3A0F4923EEB6424 CRC64;
MPYELKKVFA SLPQMERGVA KILAGDPKGN NFLYTNGKSV IIRNIDNPAI ADIYTEHAHQ
AVVARYAPSG FYIASGDTSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV
GEGREKFASV FLWDTGSSVG EITGNIKVIN SVDIKQTRPY RLVTGSDDNC CAFLEGPPFK
FKFTMSDHSR FVNCVRFSPD GSKLASAGAD GQIFLYDGKT GEKVCSLGGS KAHDGGIYAV
SWSPDGTQLL SASGDKTTKI WDVAANSAVT TFNLGSDVLD QQLGCLWQKD YLLSVSLSGY
INYLDKNNPA RPLRVIKGHN KSIQCMTVNN SDGRSTIYTG SHDGHINYWD AETGENDTFT
GKGHTNQVSS MDLDGCNQLI TCSMDDTLRY TSLISKDYSS SESVKMDVQP KCVAVGSGGY
VVTVCIGQIV LLKDKKKVFA IDSLDYEPEA VAIHKGSGTV AVGGADGKVH LYSIQGNSLK
DEGKTLPAKG AVTDLAYSHD GAFLAVTDAN KVVTVFSVAD GYSEKNSYYG HHAKALSVAW
SPDNEHFASS GMDMMVYVWT LSDPDTRIKM PDAHRLHHVS SLAWLDEHTL ATVSHDACVK
QWTVTFK
