ID   WDR1B_XENLA             Reviewed;         607 AA.
AC   Q6PAX7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=WD repeat-containing protein 1-B;
DE   AltName: Full=Actin-interacting protein 1-B;
DE            Short=xAIP1-B;
GN   Name=wdr1-b; Synonyms=aip1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH60007.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH60007.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces disassembly of actin filaments in conjunction with
CC       ADF/cofilin family proteins. Doesn't sever actin filaments alone, but
CC       caps the barbed ends of filaments severed by cofilin, which blocks
CC       annealing and depolymerization and allows more extensive severing by
CC       cofilin (By similarity). {ECO:0000250|UniProtKB:Q9W7F2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9W7F2}.
CC       Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9W7F2}.
CC   -!- SIMILARITY: Belongs to the WD repeat AIP1 family. {ECO:0000255}.
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DR   EMBL; BC060007; AAH60007.1; -; mRNA.
DR   RefSeq; NP_001083198.1; NM_001089729.1.
DR   AlphaFoldDB; Q6PAX7; -.
DR   SMR; Q6PAX7; -.
DR   DNASU; 398797; -.
DR   GeneID; 398797; -.
DR   KEGG; xla:398797; -.
DR   CTD; 398797; -.
DR   Xenbase; XB-GENE-865912; wdr1.S.
DR   OrthoDB; 325552at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 398797; Expressed in brain and 19 other tissues.
DR   GO; GO:0005884; C:actin filament; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0030043; P:actin filament fragmentation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50974; SSF50974; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..607
FT                   /note="WD repeat-containing protein 1-B"
FT                   /id="PRO_0000289068"
FT   REPEAT          4..45
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          48..87
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          93..135
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          138..176
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          180..218
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          224..263
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          270..306
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          311..351
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          358..408
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          432..474
FT                   /note="WD 10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          480..518
FT                   /note="WD 11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          523..561
FT                   /note="WD 12"
FT                   /evidence="ECO:0000255"
FT   REPEAT          566..604
FT                   /note="WD 13"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   607 AA;  66169 MW;  1E82176B3D9E595D CRC64;
     MPYEIKKVFA SLPQVERGVA KIIAGDPKGN NFLYTNGKSV IIRNIDNPAI ADIYTEHAHQ
     VVVARYAPSG FYIASGDTSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV
     GEGREKFGSV FLWDTGSSVG EIIGNIKVIN SVDIKQTRPY RLVTGSDDNC CAFFEGPPFK
     FKFTMSDHSR FVNCVRFSPD GSRLASAGAD GQIFLYDGKT GEKVCSLGGS KAHDGGIYAV
     SWSPDGTQLL SASGDKTAKI WDVAANSAVT TFNLGSDVLD QQLGCLWQKD YLLSVSLSGY
     INYLDKNNPA KPFRIIKGHN KSIQCMTVDK SDGRSTIYTG SHDGHINYWD AETGENNTFT
     GKGHTNQVSS MDLDGSSQLI TCSMDDTLRY TNLISKDYSS SESVKMDVQP KCVAVGSGGY
     VVTVCIGQIV LLKDKKKVFA IDSLDYEPEA VAIHKGSGTV SVGGADGKVH LYSIQGNSLK
     DEGKTLPAKG AVTDLAYSPD GAFLAVTDAN KVVTVFSVAD GYSEHNSYYG HHAKALSVAW
     SPDNEHFASS GMDMMVYVWT LSDPDTRIKM PDAHRLHHVS SLAWLDENTL ATVSHDACVK
     QWTVTFK