WDR1_BOVIN
ID WDR1_BOVIN Reviewed; 606 AA.
AC Q2KJH4;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=WD repeat-containing protein 1;
GN Name=WDR1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Induces disassembly of actin filaments in conjunction with
CC ADF/cofilin family proteins. Enhances cofilin-mediated actin severing.
CC Involved in cytokinesis. Involved in chemotactic cell migration by
CC restricting lamellipodial membrane protrusions. Involved in myocardium
CC sarcomere organization. Required for cardiomyocyte growth and
CC maintenance. Involved in megakaryocyte maturation and platelet
CC shedding. Required for the establishment of planar cell polarity (PCP)
CC during follicular epithelium development and for cell shape changes
CC during PCP; the function seems to implicate cooperation with CFL1
CC and/or DSTN/ADF. Involved in the generation/maintenance of cortical
CC tension. Involved in assembly and maintenance of epithelial apical cell
CC junctions and plays a role in the organization of the perijunctional
CC actomyosin belt (By similarity). {ECO:0000250|UniProtKB:O75083,
CC ECO:0000250|UniProtKB:O88342}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome
CC {ECO:0000250|UniProtKB:O75083}.
CC -!- SIMILARITY: Belongs to the WD repeat AIP1 family. {ECO:0000305}.
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DR EMBL; BC105341; AAI05342.1; -; mRNA.
DR RefSeq; NP_001039811.1; NM_001046346.2.
DR AlphaFoldDB; Q2KJH4; -.
DR SMR; Q2KJH4; -.
DR STRING; 9913.ENSBTAP00000018092; -.
DR PaxDb; Q2KJH4; -.
DR PeptideAtlas; Q2KJH4; -.
DR PRIDE; Q2KJH4; -.
DR GeneID; 533223; -.
DR KEGG; bta:533223; -.
DR CTD; 9948; -.
DR eggNOG; KOG0318; Eukaryota.
DR InParanoid; Q2KJH4; -.
DR OrthoDB; 325552at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011045; N2O_reductase_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50974; SSF50974; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Actin-binding; Cell junction; Cell projection; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..606
FT /note="WD repeat-containing protein 1"
FT /id="PRO_0000259955"
FT REPEAT 4..45
FT /note="WD 1"
FT REPEAT 48..87
FT /note="WD 2"
FT REPEAT 93..135
FT /note="WD 3"
FT REPEAT 138..176
FT /note="WD 4"
FT REPEAT 180..218
FT /note="WD 5"
FT REPEAT 224..263
FT /note="WD 6"
FT REPEAT 270..306
FT /note="WD 7"
FT REPEAT 311..351
FT /note="WD 8"
FT REPEAT 358..408
FT /note="WD 9"
FT REPEAT 432..474
FT /note="WD 10"
FT REPEAT 480..518
FT /note="WD 11"
FT REPEAT 523..561
FT /note="WD 12"
FT REPEAT 566..604
FT /note="WD 13"
FT MOD_RES 28
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75083"
FT MOD_RES 81
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75083"
FT MOD_RES 95
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75083"
FT MOD_RES 115
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75083"
FT MOD_RES 238
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O75083"
FT MOD_RES 480
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75083"
SQ SEQUENCE 606 AA; 66258 MW; 85B08DD828F2A439 CRC64;
MPYEIKKVFA SLPQVERGVS KIVGGDPKGN SFLYTNGKCV ILRNIDNPAI ADIYTEHAHQ
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV
GEGREKFGAV FLWDSGSSVG EITGHNKVIN SVDIKQSRPY RLVTGSDDNC AAFFEGPPFK
FKFTISDHGR FVNCVRFSPD GNRFATASAD GQIFIYDGKT GEKVCALGGS KAHDGGIYAI
SWSPDSTHLL SASGDKTSKI WDVNVNSVVN TFTMGSNVLD QQLGCLWQKD HLLSISLSGY
INYLDKNNPS KPLRVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD SETGENDSFA
GKGHTNQVSR MTVDEHGQLV SCSMDDTVRY TNLTLRDYSG QGVVKLDVQP KCLAVGPGGY
TVVVCIGQIV LLKDQRKCFS IDNPGYEPEV VAVHPGGETV AVGGADGNVR LYSILGTTLK
DEGKLLEAKG PVTDLAFSHD GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW
SPDNEHFASG GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK
EWTIAY