ID   WDR1_CHICK              Reviewed;         609 AA.
AC   O93277;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=WD repeat-containing protein 1;
DE   AltName: Full=Actin-interacting protein 1;
DE            Short=AIP1;
GN   Name=WDR1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10036186; DOI=10.1006/geno.1998.5672;
RA   Adler H.J., Winnicki R.S., Gong T.-W.L., Lomax M.I.;
RT   "A gene upregulated in the acoustically damaged chick basilar papilla
RT   encodes a novel WD40 repeat protein.";
RL   Genomics 56:59-69(1999).
CC   -!- FUNCTION: Induces disassembly of actin filaments in conjunction with
CC       ADF/cofilin family proteins. Enhances cofilin-mediated actin severing
CC       (By similarity). {ECO:0000250|UniProtKB:O75083,
CC       ECO:0000250|UniProtKB:O88342}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q5RKI0}.
CC   -!- SIMILARITY: Belongs to the WD repeat AIP1 family. {ECO:0000305}.
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DR   EMBL; AF020054; AAD05042.1; -; mRNA.
DR   RefSeq; NP_001004402.1; NM_001004402.1.
DR   AlphaFoldDB; O93277; -.
DR   SMR; O93277; -.
DR   STRING; 9031.ENSGALP00000024078; -.
DR   PaxDb; O93277; -.
DR   GeneID; 422842; -.
DR   KEGG; gga:422842; -.
DR   CTD; 9948; -.
DR   VEuPathDB; HostDB:geneid_422842; -.
DR   eggNOG; KOG0318; Eukaryota.
DR   InParanoid; O93277; -.
DR   OrthoDB; 325552at2759; -.
DR   PhylomeDB; O93277; -.
DR   PRO; PR:O93277; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50974; SSF50974; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..609
FT                   /note="WD repeat-containing protein 1"
FT                   /id="PRO_0000051343"
FT   REPEAT          6..47
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          95..137
FT                   /note="WD 3"
FT   REPEAT          140..178
FT                   /note="WD 4"
FT   REPEAT          182..220
FT                   /note="WD 5"
FT   REPEAT          226..265
FT                   /note="WD 6"
FT   REPEAT          272..308
FT                   /note="WD 7"
FT   REPEAT          313..353
FT                   /note="WD 8"
FT   REPEAT          360..410
FT                   /note="WD 9"
FT   REPEAT          434..476
FT                   /note="WD 10"
FT   REPEAT          482..520
FT                   /note="WD 11"
FT   REPEAT          525..563
FT                   /note="WD 12"
FT   REPEAT          568..606
FT                   /note="WD 13"
SQ   SEQUENCE   609 AA;  66567 MW;  1DE89BE431DEE32A CRC64;
     MRMPYEIKKV FASLPQVERG VSKIIGGDPK GNNFLYTNGK CVVIRNIDNP AIADIYTEHA
     HQVVVAKYAP SGFYIASGDV SGKLRIWDTT QKEHLLKYEY QPFAGKIKDL AWTEDSKRIA
     VVGEGREKFG AVFLWDSGSS VGEITGHNKV INSVDIKQTR PYRLATGSDD NCAAFFEGPP
     FKFKFTLSDH TRFVNCVRFS PDGNRFATAS ADGQIFIYDG KTGEKVCALG GGKAHDGGIY
     AISWSPDSSQ LLSASGDKTA KIWDVGANSV VSTFNMGSNV LDQQLGCLWQ KDHLLSLSLS
     GYINYLDKNN PDKPLRVIKG HSKSIQCLTV HKNGGKSYIY SGSNDGHINY WDSDTGENDG
     FSGKGHTNQV SRMAVDEMDQ LVTCSMDDTV RYTNLSKRDY SGQDAVKMDV QPKCLAVGPG
     GYTVVLCIGQ IVLMKDKKKC FAIDDLGYEP EAVAVHPGGG SVAVGGTDGN VRLYSIQGTS
     LKSDDKTLEA KGPVTDLAYS HDGAFLAVCD ANKVVTVFSV PDGYVEHNVF YGHHAKVVCI
     AWSPDNEHFA SGGMDMMVYV WTVSDPETRI KIPDAHRLHH VSGLAWLDEH TLVTTSHDAS
     VKEWSISYN