WDR1_XENTR
ID WDR1_XENTR Reviewed; 607 AA.
AC Q6DIF4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=WD repeat-containing protein 1;
DE AltName: Full=Actin-interacting protein 1;
DE Short=AIP1;
GN Name=wdr1 {ECO:0000312|EMBL:AAH75588.1};
GN Synonyms=aip1 {ECO:0000250|UniProtKB:Q9W7F2};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAH75588.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAH75588.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Induces disassembly of actin filaments in conjunction with
CC ADF/cofilin family proteins. Doesn't sever actin filaments alone, but
CC caps the barbed ends of filaments severed by cofilin, which blocks
CC annealing and depolymerization and allows more extensive severing by
CC cofilin (By similarity). {ECO:0000250|UniProtKB:Q9W7F2}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9W7F2}.
CC Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250|UniProtKB:Q9W7F2}.
CC -!- SIMILARITY: Belongs to the WD repeat AIP1 family. {ECO:0000255}.
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DR EMBL; BC075588; AAH75588.1; -; mRNA.
DR RefSeq; NP_001006781.1; NM_001006780.1.
DR AlphaFoldDB; Q6DIF4; -.
DR SMR; Q6DIF4; -.
DR STRING; 8364.ENSXETP00000064033; -.
DR DNASU; 448473; -.
DR GeneID; 448473; -.
DR KEGG; xtr:448473; -.
DR CTD; 9948; -.
DR Xenbase; XB-GENE-489897; wdr1.
DR eggNOG; KOG0318; Eukaryota.
DR InParanoid; Q6DIF4; -.
DR OrthoDB; 325552at2759; -.
DR Reactome; R-XTR-114608; Platelet degranulation.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005884; C:actin filament; ISS:UniProtKB.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0030042; P:actin filament depolymerization; IBA:GO_Central.
DR GO; GO:0030043; P:actin filament fragmentation; ISS:UniProtKB.
DR GO; GO:0040011; P:locomotion; IBA:GO_Central.
DR GO; GO:0030836; P:positive regulation of actin filament depolymerization; IBA:GO_Central.
DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011045; N2O_reductase_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50974; SSF50974; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..607
FT /note="WD repeat-containing protein 1"
FT /id="PRO_0000289069"
FT REPEAT 4..45
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 48..87
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 93..135
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 138..176
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 180..218
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 224..263
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 270..306
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 311..351
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 358..408
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REPEAT 432..474
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT REPEAT 480..518
FT /note="WD 11"
FT /evidence="ECO:0000255"
FT REPEAT 523..561
FT /note="WD 12"
FT /evidence="ECO:0000255"
FT REPEAT 566..604
FT /note="WD 13"
FT /evidence="ECO:0000255"
SQ SEQUENCE 607 AA; 66311 MW; 62EB98B658E90395 CRC64;
MPYELKKVFA SLPQVERGVA KIITGDPKGN NFLYTNGKSV IIRNIENPAI ADIYTEHAHP
VVVARYAPSG FYIASGDTSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV
GEGREKFGSV FLWDTGSSVG EISGNIKVIN SVDIKQTRPY RLVTGSDDNC CAFFEGPPFK
FKFTMADHSR FVNCVRFSPD GSRLASAGAD GQIFLYDGKT GEKVGNLGGS KAHDGGIYAV
SWSADSTQLL SASGDKTAKI WDVAANSAVT TFHLGTEVLD QQLGCLWQKD YLLSVSLSGY
INYLDKNNPS RPLRVIKGHN KSIQCMTVHN SDGRSTIYTG SHDGHINYWD AETGENDTFT
GKGHTNQVSR MDLDSSNQLI TCSMDDTVRY TSLTSKDYSS SESVKMDVQP KCVAVGSGGY
VVTLCIGQIV LLKDKKKVFA IDSLDYEPEA VAIHKGSGTV AVGGVDGNVH LYSIQGNSLK
DEGKSLPVKG AVTDLAYSHD GAFLAVTDAN KVVTVFNVAD GYSEQNVYYG HHAKAVSVAW
SPDNEHFASS GMDMMVYVWT LSDPDARIKI PDAHRLHHVS SLAWLDEHTL ATVSHDACVK
QWTVTFK
