WDR20_MOUSE
ID WDR20_MOUSE Reviewed; 567 AA.
AC Q9D5R2; Q80X67; Q9D5L0;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=WD repeat-containing protein 20;
GN Name=Wdr20; Synonyms=Wdr20b, Wdr20rt;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC deubiquitinating activity of complexes containing USP12.
CC {ECO:0000250|UniProtKB:P62068}.
CC -!- SUBUNIT: Interacts with USP12. Component of the USP12/WDR20/WDR48
CC deubiquitinating complex. Interacts with USP46.
CC {ECO:0000250|UniProtKB:P62068}.
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DR EMBL; AK015014; BAB29671.1; -; mRNA.
DR EMBL; AK015210; BAB29747.2; -; mRNA.
DR EMBL; BC050778; AAH50778.1; -; mRNA.
DR CCDS; CCDS25943.1; -.
DR RefSeq; NP_081890.1; NM_027614.1.
DR AlphaFoldDB; Q9D5R2; -.
DR SMR; Q9D5R2; -.
DR BioGRID; 214364; 5.
DR STRING; 10090.ENSMUSP00000036682; -.
DR iPTMnet; Q9D5R2; -.
DR PhosphoSitePlus; Q9D5R2; -.
DR jPOST; Q9D5R2; -.
DR MaxQB; Q9D5R2; -.
DR PaxDb; Q9D5R2; -.
DR PeptideAtlas; Q9D5R2; -.
DR PRIDE; Q9D5R2; -.
DR DNASU; 70948; -.
DR Ensembl; ENSMUST00000046331; ENSMUSP00000036682; ENSMUSG00000035560.
DR GeneID; 70948; -.
DR KEGG; mmu:70948; -.
DR UCSC; uc007nrk.1; mouse.
DR CTD; 70948; -.
DR MGI; MGI:1918198; Wdr20rt.
DR VEuPathDB; HostDB:ENSMUSG00000035560; -.
DR eggNOG; KOG2394; Eukaryota.
DR GeneTree; ENSGT00390000007686; -.
DR HOGENOM; CLU_005019_2_1_1; -.
DR InParanoid; Q9D5R2; -.
DR OMA; QPTCHDI; -.
DR OrthoDB; 907634at2759; -.
DR PhylomeDB; Q9D5R2; -.
DR TreeFam; TF314961; -.
DR BioGRID-ORCS; 70948; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Wdr20; mouse.
DR PRO; PR:Q9D5R2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D5R2; protein.
DR Bgee; ENSMUSG00000035560; Expressed in spermatocyte and 28 other tissues.
DR ExpressionAtlas; Q9D5R2; baseline and differential.
DR Genevisible; Q9D5R2; MM.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT CHAIN 2..567
FT /note="WD repeat-containing protein 20"
FT /id="PRO_0000051367"
FT REPEAT 147..187
FT /note="WD 1"
FT REPEAT 216..257
FT /note="WD 2"
FT REPEAT 258..297
FT /note="WD 3"
FT REPEAT 345..389
FT /note="WD 4"
FT REPEAT 529..566
FT /note="WD 5"
FT REGION 408..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT MOD_RES 358
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT MOD_RES 463
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBZ3"
FT CONFLICT 124
FT /note="A -> V (in Ref. 2; AAH50778)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 567 AA; 62782 MW; 13B4550D938248C4 CRC64;
MATEGRGKET NEIKTHFTTR EGLYRLLPHS EYSRPNRVPF NSQGSNPVRV SFVNLNDQTG
NGNRLCFSVG RELYVYIYKG VRKAADLSKP IDKRIYKGTQ PTCHDFNHLT ATAESVSLLV
GFSAGQVQLI DPIKKETSKL FNEERLIDKS RVTCVKWVPG SDSLFLVAHS SGNMYSYNVE
HTYGTTAPHY QLLKQGESFA VHNCKSKSTR DLKWTVGEGA LNEFAFSPDG KFLACVSQDG
FLRVFNFDSA ELHGTMKSYF GGLLCLCWSP DGKYIVTGGE DDLVTVWSFL DCRVIARGRG
HKSWVSVVAF DPYTTSVEES DPMEFSDSDK NFQDLLHFGR DRANSTQSRL SKQNSTDSRP
VSVTYRFGSV GQDTQLCLWD LTEDILFPHQ PLSRARAHAN VMNATGLPAG SNGSAVTTPG
NSVPPPLPRS NSLPHSAVSN AASKGSVMDG AITSGVSKFA LLSLHDRKER HHEKDRKRNH
SMGHISSKSS DKLNLVNKAK TDPAKTLGTS LCPRMEDVPL LEPLICKKIA HERLTVLVFL
EDCIVTACQE GFICTWARPG KVSKFQP
