WDR21_SCHPO
ID WDR21_SCHPO Reviewed; 420 AA.
AC Q09873;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=WD repeat-containing protein 21;
GN Name=wdr21; ORFNames=SPAC12G12.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DDB1, AND DOMAIN.
RX PubMed=18794354; DOI=10.1128/mcb.00757-08;
RA Fukumoto Y., Dohmae N., Hanaoka F.;
RT "Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor
RT proteins through a novel protein motif, the DDB-box.";
RL Mol. Cell. Biol. 28:6746-6756(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- DOMAIN: The DDB-box is specifically required for ddb1-binding.
CC {ECO:0000269|PubMed:18794354}.
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DR EMBL; CU329670; CAA91505.1; -; Genomic_DNA.
DR PIR; S62541; S62541.
DR RefSeq; NP_592888.1; NM_001018288.2.
DR AlphaFoldDB; Q09873; -.
DR SMR; Q09873; -.
DR BioGRID; 278035; 23.
DR STRING; 4896.SPAC12G12.10.1; -.
DR MaxQB; Q09873; -.
DR PaxDb; Q09873; -.
DR EnsemblFungi; SPAC12G12.10.1; SPAC12G12.10.1:pep; SPAC12G12.10.
DR GeneID; 2541535; -.
DR KEGG; spo:SPAC12G12.10; -.
DR PomBase; SPAC12G12.10; wdr21.
DR VEuPathDB; FungiDB:SPAC12G12.10; -.
DR eggNOG; KOG2695; Eukaryota.
DR HOGENOM; CLU_613968_0_0_1; -.
DR InParanoid; Q09873; -.
DR OMA; TESKAHM; -.
DR PhylomeDB; Q09873; -.
DR Reactome; R-SPO-8951664; Neddylation.
DR PRO; PR:Q09873; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISO:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0070913; C:Ddb1-Wdr21 complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006282; P:regulation of DNA repair; IC:PomBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..420
FT /note="WD repeat-containing protein 21"
FT /id="PRO_0000116429"
FT REPEAT 251..289
FT /note="WD 1"
FT REPEAT 293..332
FT /note="WD 2"
FT REPEAT 341..383
FT /note="WD 3"
FT MOTIF 73..75
FT /note="DDB-boX"
SQ SEQUENCE 420 AA; 47525 MW; 9DC1F710FBEB9761 CRC64;
MSGLPFHIPG YYYNSEKKRY FRIISSGQST PSSNIYTKER LKRGKRFNNI SKERTKGKGG
NPVFNFSTYL FDRQFSQYPY SCNDDRDYLC AKNLKKINLR QLPVGTELQK IGWLREVNTI
ILTSKNGDIL GCCLTPEDKS GVANEKYTSE GSIQDFSLSR IGLSNNPISS LVCNAMQIFW
STSPSLQNEG QFHISTYNQL LGESNNYRWG SLKLLKTPLC AESIGEMGFA VGGTSKIAII
NREGKLTQSL QSKGDVFSLK YLGDNLVIAG CRNKSVLVYD LRTKKECVQR FYHGSSICSM
QNLDFSQPKL LVSGLESKIS LYDCRFLQSK KRPQSIMSYM GHSNLLERNL ALMKNENGSI
FSSAGDDYVL RFWKTDCSLP FKEMRVDDGK YLCRDGSWVK AMNGTGWVLP YGRGLLIYEP
