ID   WDR24_CHICK             Reviewed;         705 AA.
AC   Q5ZMV9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=GATOR complex protein WDR24 {ECO:0000305};
GN   Name=WDR24 {ECO:0000250|UniProtKB:Q96S15};
GN   ORFNames=RCJMB04_1a19 {ECO:0000312|EMBL:CAG30934.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR24 family. {ECO:0000305}.
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DR   EMBL; AJ719275; CAG30934.1; -; mRNA.
DR   RefSeq; NP_001025799.1; NM_001030628.1.
DR   AlphaFoldDB; Q5ZMV9; -.
DR   SMR; Q5ZMV9; -.
DR   STRING; 9031.ENSGALP00000003853; -.
DR   PaxDb; Q5ZMV9; -.
DR   Ensembl; ENSGALT00000003862; ENSGALP00000003853; ENSGALG00000002450.
DR   GeneID; 416406; -.
DR   KEGG; gga:416406; -.
DR   CTD; 84219; -.
DR   VEuPathDB; HostDB:geneid_416406; -.
DR   eggNOG; KOG0269; Eukaryota.
DR   GeneTree; ENSGT00940000159396; -.
DR   HOGENOM; CLU_010233_0_0_1; -.
DR   InParanoid; Q5ZMV9; -.
DR   OMA; QDGTMKC; -.
DR   OrthoDB; 590848at2759; -.
DR   PhylomeDB; Q5ZMV9; -.
DR   TreeFam; TF314190; -.
DR   Reactome; R-GGA-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q5ZMV9; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000002450; Expressed in cerebellum and 12 other tissues.
DR   ExpressionAtlas; Q5ZMV9; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0061700; C:GATOR2 complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; IBA:GO_Central.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037590; WDR24.
DR   PANTHER; PTHR46200; PTHR46200; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..705
FT                   /note="GATOR complex protein WDR24"
FT                   /id="PRO_0000051377"
FT   REPEAT          1..28
FT                   /note="WD 1"
FT   REPEAT          34..74
FT                   /note="WD 2"
FT   REPEAT          77..117
FT                   /note="WD 3"
FT   REPEAT          121..161
FT                   /note="WD 4"
FT   REPEAT          165..207
FT                   /note="WD 5"
FT   REPEAT          211..254
FT                   /note="WD 6"
SQ   SEQUENCE   705 AA;  80210 MW;  1C2A4C7B5A928401 CRC64;
     MDENLLATAA TNGVVVTWNL GKPSRNKQDQ LFTEHKRTVN KVCFHPTEVY MLLSGSQDGY
     MKCFDLRKKD SVSTFSGQSE SVRDVQFSIR DYFTFAATFE NGNVQLWDIR RPDRYERMFT
     AHNGPVFCCD WHPEDRGWLA TGGRDKMVKV WDMNTTRAKE IYCVQTIASV ARVKWRPECK
     HHIATCSMMV DHNIYVWDVR RPFIPSAMFE EHKDVTTGIV WRHLHDPYFL LSGSKDSTLY
     QHIFKDASQP IDRANPEGLC YSLYGDLAFA AKESLISSDS NRKPYIGDRR HPIFFKRKLD
     PTEQFEYISS SSALSVFETD VESGSMDWFV HTAKQYALAG RPLAELCDHN AKVAKGLDRN
     QVAQTWTMLR IIYSSLGTVS STNLNHSMGK GSTTLPLMNS FNLKDIPSGL GSESRLDRSK
     GESRTENILM DSSSTLINNE DNEETEGSDV PADYLLGDVE ADEDDLYMMD HENPHAEEQE
     YSLPQEAFPL RHEIVDNPSA LDHLQDKADS PHVSGNEAET VSLTPVESFS LISISHSLYE
     NRLPSDFFNP IVRDTLLFYA EQGDVQTAVS VLIVLGDRIR KEIDEQTQEH WYTSYIDLLQ
     RFQLWNISNE VIKLSTCRAI NCLNQASTTL HINCSNCKRP MSNRGWICDR CRQCASMCAV
     CHHVVKGLFV WCQGCSHGGH LQHIMKWLET SSHCPAGCGH LCEYT