ID   WDR24_DANRE             Reviewed;         779 AA.
AC   Q7ZVL2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=GATOR complex protein WDR24 {ECO:0000305};
GN   Name=wdr24 {ECO:0000250|UniProtKB:Q96S15};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR24 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC045501; AAH45501.1; -; mRNA.
DR   RefSeq; NP_998228.1; NM_213063.1.
DR   AlphaFoldDB; Q7ZVL2; -.
DR   SMR; Q7ZVL2; -.
DR   STRING; 7955.ENSDARP00000008451; -.
DR   PaxDb; Q7ZVL2; -.
DR   GeneID; 406336; -.
DR   KEGG; dre:406336; -.
DR   CTD; 84219; -.
DR   ZFIN; ZDB-GENE-040426-2012; wdr24.
DR   eggNOG; KOG0269; Eukaryota.
DR   InParanoid; Q7ZVL2; -.
DR   OrthoDB; 590848at2759; -.
DR   PhylomeDB; Q7ZVL2; -.
DR   Reactome; R-DRE-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q7ZVL2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0061700; C:GATOR2 complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; IBA:GO_Central.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037590; WDR24.
DR   PANTHER; PTHR46200; PTHR46200; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..779
FT                   /note="GATOR complex protein WDR24"
FT                   /id="PRO_0000051378"
FT   REPEAT          66..106
FT                   /note="WD 1"
FT   REPEAT          112..152
FT                   /note="WD 2"
FT   REPEAT          155..195
FT                   /note="WD 3"
FT   REPEAT          199..239
FT                   /note="WD 4"
FT   REPEAT          243..285
FT                   /note="WD 5"
FT   REPEAT          289..332
FT                   /note="WD 6"
FT   REGION          506..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   779 AA;  88855 MW;  B9080162017638D8 CRC64;
     MEKMTRVSTI NGRTMFCHLD APANAISVCR DATQVVVAGR NIFKIYGLEE DGFVERLNLR
     VGRKPSLNFS CADVMWHQME ENLLATAATN GAVVTWNLSR PCRNKQEQLF TEHKRTVNKV
     CFHPTEVNML LSGSQDGFMK CFDLRKKESV STFSGQSESV RDVQFSMKDY FTFAASFENG
     NVQLWDIRRP DRYERMFTAH TGPVFCCDWH PEDRGWLATG GRDKMVKVWD MSTNRVKEIY
     CVQTFASVAR VKWRPERRYH LATCSMMVDH NIYVWDVRRP FIPFATFEEH KDVTTGIVWR
     HQHDPYFLLS GSKDSTLYQH MFKDASRPVD RANPEGLCFG LFGDLAFAAK ESLMSAPASA
     GDVGRKTYPG GDRRYPIFFF KKPDVTEQFA QVSSALSVFE SEADSSAGMD WFINTAQSYL
     LSGKPFAELC EHNAHVAKSL NRPQESTTWT MLRIMFSEPA NPSLSTNHNL NKSGNLPLVN
     SFSMKEMSGA LNERNKENRQ DNIHSLETNL NNNDENEETE GSEGQAEYLF VDDELDDDEL
     YSMEHDNQPA EESEYLLPQE AFPLRHEIMD HPSAPEPLQE KQESPHVSGS EAESMCLTPM
     ESFSLISVSQ QLFSPHLPPK FFCPIVKEML CYYAEQGDVQ MAVSVLIVLG DRIRKEIDEL
     MQEHWYMSYI DLLQRFELWN VSNEVIKLST CGAIMCLNQA STTLHINCSN CKRPMSNKGW
     ICDRCHQCAS VCAVCHHVVK GLFVWCQGCS HGGHLEHVME WLKQSKHCPA GCGHLCEYT