WDR24_DICDI
ID WDR24_DICDI Reviewed; 1023 AA.
AC Q54JS5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=GATOR complex protein WDR24 {ECO:0000305};
GN Name=wdr24 {ECO:0000250|UniProtKB:Q96S15}; ORFNames=DDB_G0287817;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC acid-sensing branch of the TORC1 signaling pathway.
CC {ECO:0000250|UniProtKB:Q9NXC5}.
CC -!- SUBUNIT: Probably part of the GATOR complex.
CC {ECO:0000250|UniProtKB:Q96S15}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96S15}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR24 family. {ECO:0000305}.
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DR EMBL; AAFI02000104; EAL63555.1; -; Genomic_DNA.
DR RefSeq; XP_637077.1; XM_631985.1.
DR AlphaFoldDB; Q54JS5; -.
DR SMR; Q54JS5; -.
DR STRING; 44689.DDB0304352; -.
DR PaxDb; Q54JS5; -.
DR PRIDE; Q54JS5; -.
DR EnsemblProtists; EAL63555; EAL63555; DDB_G0287817.
DR GeneID; 8626332; -.
DR KEGG; ddi:DDB_G0287817; -.
DR dictyBase; DDB_G0287817; wdr24.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_010233_0_0_1; -.
DR InParanoid; Q54JS5; -.
DR OMA; QDGTMKC; -.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q54JS5; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0061700; C:GATOR2 complex; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR PANTHER; PTHR46200; PTHR46200; 2.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1023
FT /note="GATOR complex protein WDR24"
FT /id="PRO_0000356839"
FT REPEAT 16..54
FT /note="WD 1"
FT REPEAT 64..108
FT /note="WD 2"
FT REPEAT 114..154
FT /note="WD 3"
FT REPEAT 159..199
FT /note="WD 4"
FT REPEAT 203..243
FT /note="WD 5"
FT REPEAT 245..287
FT /note="WD 6"
FT REPEAT 291..329
FT /note="WD 7"
FT REGION 563..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..596
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..758
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 117500 MW; 855AD6F291A4CE0C CRC64;
MNQMNQPPNK CQTYLNLGSP LSAISSSPDS TKLIVAGRDI VKIVSVQNNE FKVTSNLRAG
KTQSLNYTGN DCCWHPSLLE NYRFLIATAA TNGAVVIWNT VREGSKSVER VFTDHSRAVN
KLAWHPEKLD CILTGSQDNT LRMWDIRDSA NASKITFSPK SESIRDVQFN PSQANQFAAA
FDNGTIQLWD IRKPTIAVEK ITSHQGLVLT IDWHPEEKNI IASGGRDRAI RVWDFSNGKS
LNNVSTISSV SRIKWRPGNK WHIASCSSIV DFQIHIWDVK KPYIPLFSFT DHRDVPTGLI
WKSPSSLISC SKDSHLLLNE FQDSYKPYQH IRTTGITWNV NNELASINDK INRTQSNESL
PSLSTQFPSF FASFNVPTPP PLPPLVKVEQ GIMNIYTPKY QNSEIVYDEK YLFEHFAKNY
RFRGESFNQL CDHNQFVSQS VNQHHISTMW SLLKLHYSNL DEIQQHKELI EQQQKEELEK
LNNKKIEKQQ PQKLKKQQQQ QQQQQQQQQQ QSQQQLQQPQ LQQPQQQQQL QQPQQQLRQQ
NDKNIKEQQI QYIENLENKQ LDSKNIIDNS NDSNQEININ KEDKEDEEED DDNTSNNLDD
NQMGDIFDPS NDMMTAKEPP SSSLMEFNAN DTGNDQFCNI LSAEAVTPLV SLPTSISLER
QKSTDNISDN NSNVHVNIKR QNQPTNNNNN NSNIDNLEKK SNKSKSTKEN KESSLTDQNK
QKRNDNKEKI DNNEIDNDNK DNNDDDDNDV DNIGEDNDEI NNNNDNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNKNN NNDNNNNNNI NNKKNKIKNK SIENKKDILD KKEINDEDNK
SNDENDSLKI LIPCFEFEEF NFQPIITDML EACIEKGDVQ TCVFIVLILG RYMDLNIEKH
RLTTWFGSYI ELLQRYKMWS LALEVMKYCD DQIINQASKR HTTLISACSS CGKSIPQNSI
ICEKCNKASS KCSICRLPVK GMWVWCQGCG HGGHLEHMKS WFIDKNQKSC PTGCTHICTP
FKK
