ID   WDR24_XENLA             Reviewed;         780 AA.
AC   Q7ZX22;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=GATOR complex protein WDR24 {ECO:0000305};
GN   Name=wdr24 {ECO:0000250|UniProtKB:Q96S15};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR24 family. {ECO:0000305}.
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DR   EMBL; BC046252; AAH46252.1; -; mRNA.
DR   RefSeq; NP_001080665.1; NM_001087196.1.
DR   RefSeq; XP_018096884.1; XM_018241395.1.
DR   RefSeq; XP_018096885.1; XM_018241396.1.
DR   RefSeq; XP_018096886.1; XM_018241397.1.
DR   AlphaFoldDB; Q7ZX22; -.
DR   SMR; Q7ZX22; -.
DR   DNASU; 380357; -.
DR   GeneID; 380357; -.
DR   KEGG; xla:380357; -.
DR   CTD; 380357; -.
DR   Xenbase; XB-GENE-5898590; wdr24.L.
DR   OrthoDB; 590848at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 380357; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037590; WDR24.
DR   PANTHER; PTHR46200; PTHR46200; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..780
FT                   /note="GATOR complex protein WDR24"
FT                   /id="PRO_0000051379"
FT   REPEAT          67..107
FT                   /note="WD 1"
FT   REPEAT          113..153
FT                   /note="WD 2"
FT   REPEAT          156..196
FT                   /note="WD 3"
FT   REPEAT          200..240
FT                   /note="WD 4"
FT   REPEAT          244..286
FT                   /note="WD 5"
FT   REPEAT          290..333
FT                   /note="WD 6"
SQ   SEQUENCE   780 AA;  88520 MW;  33A5957A2F754972 CRC64;
     MERMARVTTA LTGRTMFCHL DAPANAISVC RDAAQVVVAG RNIFKIYSME EDHFVEKLNL
     RVGRKPSLNF SCADVVWHQM DDNLLATAAT NGVVVTWNLG KPSRNKQDQL FTEHKRTVNK
     VCFHPTEVYM LLSGSQDGYM KCFDLRKKDS VSTFSGQSES VRDVQFSIRD YFTFAATFEN
     GNVQLWDIRR PDRCERMFTA HNGPVFCCDW HPEDRGWLAT GGRDKMVKVW DMNTNRAKEI
     YCVQTIASVA RVKWRPERKY HIGTCSMMVD HNIYVWDVRR PFIPFATFEE HKDVTTGIIW
     RHMHDPSFLL SGSKDSTLYQ HIFRDARRPI DRANPEGLCY GLFGDLAFAA KESLISSSSS
     HDSNRKPYDR RHPIFFLRRP DPTEQFENIS SGLSVFEAGG GDMGWFVATA ERYALAGRPL
     AELCDHNANV ARDLNRWQVA QTWTMLRIIY CSPGTVPPAN PNHSLGKSGT SLPLLNSFNL
     KELPSGIVGE SRLEHSKGDS RADSILMDPA AINNDENEET EGSDVPADYL LGDVEGDEDE
     LYMMDQEQPH TEEQEYVLPQ EGFPLRHEIM DNPSALDHLQ EKADSPHVSG NEAETVSLTP
     VESFSLISIS HALYENRLPS DFFSPTVRDM LCFYAEQGDV QMAASVLIVL GDRIRKEIDE
     QTQEHWFTSY IDLLQRFKLW NVSNQVIKLS TCSSINCLNQ ASTTLHVNCS NCKRPMSNKG
     WICDRCRQCA SMCAVCHHVV KGLFVWCQGC CHGGHLQHIM NWMQNNCYCP AGCGHVCEYS