WDR25_HUMAN
ID WDR25_HUMAN Reviewed; 544 AA.
AC Q64LD2; A8K7E5; Q6NVV6; Q86TQ4; Q9BTK5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=WD repeat-containing protein 25;
GN Name=WDR25 {ECO:0000312|HGNC:HGNC:21064};
GN Synonyms=C14orf67 {ECO:0000312|HGNC:HGNC:21064};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP ARG-88.
RC TISSUE=Fetal brain;
RX PubMed=15587985; DOI=10.1023/b:bigi.0000043954.64202.61;
RA Jin F., Dai J., Ji C., Gu S., Wu M., Qian J., Xie Y., Mao Y.;
RT "A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on
RT 14q32.";
RL Biochem. Genet. 42:419-427(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ARG-88 AND
RP ARG-149.
RC TISSUE=Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-275 (ISOFORM 1).
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q64LD2; Q15323: KRT31; NbExp=3; IntAct=EBI-744560, EBI-948001;
CC Q64LD2; Q6A162: KRT40; NbExp=3; IntAct=EBI-744560, EBI-10171697;
CC Q64LD2; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-744560, EBI-945833;
CC Q64LD2; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-744560, EBI-302345;
CC Q64LD2; P36406: TRIM23; NbExp=3; IntAct=EBI-744560, EBI-740098;
CC Q64LD2-2; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-12032042, EBI-357530;
CC Q64LD2-2; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-12032042, EBI-11976299;
CC Q64LD2-2; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-12032042, EBI-12819063;
CC Q64LD2-2; A8MQ03: CYSRT1; NbExp=4; IntAct=EBI-12032042, EBI-3867333;
CC Q64LD2-2; Q92997: DVL3; NbExp=3; IntAct=EBI-12032042, EBI-739789;
CC Q64LD2-2; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-12032042, EBI-12193763;
CC Q64LD2-2; Q13643: FHL3; NbExp=3; IntAct=EBI-12032042, EBI-741101;
CC Q64LD2-2; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-12032042, EBI-12018822;
CC Q64LD2-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12032042, EBI-5916454;
CC Q64LD2-2; O75031: HSF2BP; NbExp=3; IntAct=EBI-12032042, EBI-7116203;
CC Q64LD2-2; Q15323: KRT31; NbExp=3; IntAct=EBI-12032042, EBI-948001;
CC Q64LD2-2; O76011: KRT34; NbExp=3; IntAct=EBI-12032042, EBI-1047093;
CC Q64LD2-2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12032042, EBI-11953334;
CC Q64LD2-2; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-12032042, EBI-11992140;
CC Q64LD2-2; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-12032042, EBI-9996449;
CC Q64LD2-2; O95751: LDOC1; NbExp=3; IntAct=EBI-12032042, EBI-740738;
CC Q64LD2-2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-12032042, EBI-739832;
CC Q64LD2-2; Q13064: MKRN3; NbExp=3; IntAct=EBI-12032042, EBI-2340269;
CC Q64LD2-2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-12032042, EBI-22310682;
CC Q64LD2-2; Q99471: PFDN5; NbExp=3; IntAct=EBI-12032042, EBI-357275;
CC Q64LD2-2; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-12032042, EBI-3957793;
CC Q64LD2-2; P61289: PSME3; NbExp=3; IntAct=EBI-12032042, EBI-355546;
CC Q64LD2-2; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-12032042, EBI-11139477;
CC Q64LD2-2; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-12032042, EBI-11524408;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q64LD2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q64LD2-2; Sequence=VSP_021331, VSP_021332;
CC -!- TISSUE SPECIFICITY: Expressed in heart, muscle, testis, ovary, uterus
CC and prostate. {ECO:0000269|PubMed:15587985}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY295082; AAQ63174.1; -; mRNA.
DR EMBL; AK291960; BAF84649.1; -; mRNA.
DR EMBL; AL135838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003641; AAH03641.1; -; mRNA.
DR EMBL; BX248767; CAD66574.1; -; mRNA.
DR CCDS; CCDS32157.1; -. [Q64LD2-1]
DR RefSeq; NP_001154948.1; NM_001161476.1. [Q64LD2-1]
DR RefSeq; NP_078791.3; NM_024515.4. [Q64LD2-1]
DR RefSeq; XP_005268113.1; XM_005268056.4.
DR RefSeq; XP_011535452.1; XM_011537150.2.
DR AlphaFoldDB; Q64LD2; -.
DR SMR; Q64LD2; -.
DR BioGRID; 122671; 60.
DR IntAct; Q64LD2; 30.
DR STRING; 9606.ENSP00000334148; -.
DR GlyGen; Q64LD2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q64LD2; -.
DR PhosphoSitePlus; Q64LD2; -.
DR BioMuta; WDR25; -.
DR DMDM; 126302614; -.
DR EPD; Q64LD2; -.
DR jPOST; Q64LD2; -.
DR MassIVE; Q64LD2; -.
DR MaxQB; Q64LD2; -.
DR PaxDb; Q64LD2; -.
DR PeptideAtlas; Q64LD2; -.
DR PRIDE; Q64LD2; -.
DR ProteomicsDB; 65918; -. [Q64LD2-1]
DR ProteomicsDB; 65919; -. [Q64LD2-2]
DR Antibodypedia; 174; 65 antibodies from 16 providers.
DR DNASU; 79446; -.
DR Ensembl; ENST00000335290.10; ENSP00000334148.6; ENSG00000176473.14. [Q64LD2-1]
DR Ensembl; ENST00000402312.8; ENSP00000385540.3; ENSG00000176473.14. [Q64LD2-1]
DR Ensembl; ENST00000542471.2; ENSP00000441903.2; ENSG00000176473.14. [Q64LD2-2]
DR Ensembl; ENST00000554998.5; ENSP00000450661.1; ENSG00000176473.14. [Q64LD2-1]
DR GeneID; 79446; -.
DR KEGG; hsa:79446; -.
DR MANE-Select; ENST00000402312.8; ENSP00000385540.3; NM_001161476.3; NP_001154948.1.
DR UCSC; uc001yhn.4; human. [Q64LD2-1]
DR CTD; 79446; -.
DR DisGeNET; 79446; -.
DR GeneCards; WDR25; -.
DR HGNC; HGNC:21064; WDR25.
DR HPA; ENSG00000176473; Low tissue specificity.
DR MIM; 618059; gene.
DR neXtProt; NX_Q64LD2; -.
DR OpenTargets; ENSG00000176473; -.
DR PharmGKB; PA142670607; -.
DR VEuPathDB; HostDB:ENSG00000176473; -.
DR eggNOG; KOG0282; Eukaryota.
DR GeneTree; ENSGT00530000063583; -.
DR HOGENOM; CLU_042878_0_0_1; -.
DR InParanoid; Q64LD2; -.
DR OMA; CGGFHPE; -.
DR OrthoDB; 967109at2759; -.
DR PhylomeDB; Q64LD2; -.
DR TreeFam; TF329325; -.
DR PathwayCommons; Q64LD2; -.
DR SignaLink; Q64LD2; -.
DR BioGRID-ORCS; 79446; 592 hits in 1078 CRISPR screens.
DR ChiTaRS; WDR25; human.
DR GenomeRNAi; 79446; -.
DR Pharos; Q64LD2; Tdark.
DR PRO; PR:Q64LD2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q64LD2; protein.
DR Bgee; ENSG00000176473; Expressed in adenohypophysis and 105 other tissues.
DR ExpressionAtlas; Q64LD2; baseline and differential.
DR Genevisible; Q64LD2; HS.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..544
FT /note="WD repeat-containing protein 25"
FT /id="PRO_0000256227"
FT REPEAT 244..286
FT /note="WD 1"
FT REPEAT 290..329
FT /note="WD 2"
FT REPEAT 330..373
FT /note="WD 3"
FT REPEAT 375..420
FT /note="WD 4"
FT REPEAT 424..463
FT /note="WD 5"
FT REPEAT 469..510
FT /note="WD 6"
FT REPEAT 513..544
FT /note="WD 7"
FT REGION 17..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..257
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021331"
FT VAR_SEQ 258..274
FT /note="LSKSHMLLSTSMDKTFK -> MPALCLVLCWFQGLLGE (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021332"
FT VARIANT 59
FT /note="K -> R (in dbSNP:rs2273801)"
FT /id="VAR_060042"
FT VARIANT 88
FT /note="W -> R (in dbSNP:rs2181170)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15587985"
FT /id="VAR_028888"
FT VARIANT 119
FT /note="T -> M (in dbSNP:rs34331240)"
FT /id="VAR_060043"
FT VARIANT 149
FT /note="H -> R (in dbSNP:rs2273800)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_028889"
FT CONFLICT 30
FT /note="F -> L (in Ref. 2; BAF84649)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="Q -> R (in Ref. 2; BAF84649)"
FT /evidence="ECO:0000305"
FT CONFLICT 462
FT /note="S -> I (in Ref. 1; AAQ63174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 544 AA; 60161 MW; A4E67A5574F776BD CRC64;
MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF ASGTLDVPKA
GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG KEPQVTFPIK EPSCSSLWTS
HVPASHMPLA AARFKQVKLS RNFPKSSFHA QSESETVGKN GSSFQKKKCE DCVVPYTPRR
LRQRQALSTE TGKGKDVEPQ GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF
HLRGHRGPVN TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW
APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL CGGFSSEMKA
WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR DSADRTIIAW DFRTSAKISN
QIFHERFTCP SLALHPREPV FLAQTNGNYL ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE
CSPGGDLLVT GSADGRVLMY SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM
KIWH
