WDR25_MOUSE
ID WDR25_MOUSE Reviewed; 535 AA.
AC E9Q349; Q8C4T7;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=WD repeat-containing protein 25;
GN Name=Wdr25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=E9Q349-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9Q349-2; Sequence=VSP_042397, VSP_042398;
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DR EMBL; AK081117; BAC38138.1; -; mRNA.
DR EMBL; AC122811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC140111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49172.1; -. [E9Q349-1]
DR RefSeq; NP_808270.2; NM_177602.3. [E9Q349-1]
DR RefSeq; XP_006515720.1; XM_006515657.2. [E9Q349-1]
DR RefSeq; XP_006515721.1; XM_006515658.3. [E9Q349-1]
DR RefSeq; XP_006515723.1; XM_006515660.3. [E9Q349-1]
DR RefSeq; XP_011242356.1; XM_011244054.2. [E9Q349-1]
DR RefSeq; XP_011242357.1; XM_011244055.2. [E9Q349-1]
DR AlphaFoldDB; E9Q349; -.
DR SMR; E9Q349; -.
DR STRING; 10090.ENSMUSP00000035553; -.
DR iPTMnet; E9Q349; -.
DR PhosphoSitePlus; E9Q349; -.
DR EPD; E9Q349; -.
DR MaxQB; E9Q349; -.
DR PaxDb; E9Q349; -.
DR PeptideAtlas; E9Q349; -.
DR PRIDE; E9Q349; -.
DR ProteomicsDB; 297941; -. [E9Q349-1]
DR Antibodypedia; 174; 65 antibodies from 16 providers.
DR DNASU; 212198; -.
DR Ensembl; ENSMUST00000047115; ENSMUSP00000035553; ENSMUSG00000040877. [E9Q349-1]
DR Ensembl; ENSMUST00000167816; ENSMUSP00000129855; ENSMUSG00000040877. [E9Q349-1]
DR Ensembl; ENSMUST00000221510; ENSMUSP00000152632; ENSMUSG00000040877. [E9Q349-2]
DR GeneID; 212198; -.
DR KEGG; mmu:212198; -.
DR UCSC; uc011yrx.1; mouse. [E9Q349-1]
DR CTD; 79446; -.
DR MGI; MGI:3045255; Wdr25.
DR VEuPathDB; HostDB:ENSMUSG00000040877; -.
DR eggNOG; KOG0282; Eukaryota.
DR GeneTree; ENSGT00530000063583; -.
DR HOGENOM; CLU_042878_0_0_1; -.
DR InParanoid; E9Q349; -.
DR OMA; CGGFHPE; -.
DR OrthoDB; 967109at2759; -.
DR PhylomeDB; E9Q349; -.
DR TreeFam; TF329325; -.
DR BioGRID-ORCS; 212198; 24 hits in 73 CRISPR screens.
DR ChiTaRS; Wdr25; mouse.
DR PRO; PR:E9Q349; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; E9Q349; protein.
DR Bgee; ENSMUSG00000040877; Expressed in animal zygote and 137 other tissues.
DR ExpressionAtlas; E9Q349; baseline and differential.
DR Genevisible; E9Q349; MM.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..535
FT /note="WD repeat-containing protein 25"
FT /id="PRO_0000415827"
FT REPEAT 235..277
FT /note="WD 1"
FT REPEAT 281..320
FT /note="WD 2"
FT REPEAT 321..362
FT /note="WD 3"
FT REPEAT 365..411
FT /note="WD 4"
FT REPEAT 415..454
FT /note="WD 5"
FT REPEAT 460..501
FT /note="WD 6"
FT REPEAT 504..535
FT /note="WD 7"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..352
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042397"
FT VAR_SEQ 353..357
FT /note="DMRTG -> MSEIY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042398"
SQ SEQUENCE 535 AA; 58480 MW; 3DB21C99DDB29B1A CRC64;
MASLVAYDDS DSETEADPAR SGDAAGQISD ASGMSRPSGM GFASSTVGVT KEGAQHTGNS
PNEDPGMQRL PLARLWRSDP GSCPSQRLQW PSKEPDTTFP PSEPPRPSLW MSRAPVGHVP
LAAACLKPLK PAWDVLKPSH DQSTFESTAG NASSSQRKRG EDCVLPYIPK RLRQLQALNP
EAGGGKDGEP PGPPAGCAPA PLCVAPTVSE FIQPYLNSQY RETTVPKKVL FHLRGHRGPV
NSIQWCPVFC KSHMLLSASM DKTFKVWNAV DSGHCLQTYS VHSEAVRAAR WSPCGRRILS
GGFDFALHLT DLETGTQVFS GQSDFRVTTL KFHPKDHNVF LCGGFSSEIK AWDMRTGKVV
KGYKATIQQT LDILFLQEGS EFLSSTDAST RDSADRTIIA WDFRTAAKIS NQIFHERYTC
PSLALHPREP VFLAQTNGNY LALFSSVWPY RMSRRRRYEG HKVEGYAVGC ECSPCGDLLV
TGSADGRVLM FSFRTASRAC TLQGHTQACL GTTYHPVLPS VLGTCSWGGD IKIWH
