WDR26_DROME
ID WDR26_DROME Reviewed; 630 AA.
AC Q7K0L4; A4V292;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=WD repeat-containing protein 26 homolog;
GN ORFNames=CG7611;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=17041588; DOI=10.1038/ncb1490;
RA Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.;
RT "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
RT and regulates histone methylation.";
RL Nat. Cell Biol. 8:1277-1283(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36 AND SER-40, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: G-beta-like protein involved in cell signal transduction (By
CC similarity). {ECO:0000250|UniProtKB:Q9H7D7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H7D7}.
CC Mitochondrion {ECO:0000250|UniProtKB:F1LTR1}.
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DR EMBL; AE014296; AAF51739.2; -; Genomic_DNA.
DR EMBL; AE014296; AAG22181.1; -; Genomic_DNA.
DR EMBL; AE014296; AAG22182.2; -; Genomic_DNA.
DR EMBL; AE014296; AAN12172.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN12173.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN12174.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN12175.1; -; Genomic_DNA.
DR EMBL; AY069717; AAL39862.1; -; mRNA.
DR RefSeq; NP_001163489.1; NM_001170018.2.
DR RefSeq; NP_649326.1; NM_141069.4.
DR RefSeq; NP_730644.1; NM_168913.3.
DR RefSeq; NP_730645.1; NM_168914.3.
DR RefSeq; NP_730646.1; NM_168915.3.
DR RefSeq; NP_730647.1; NM_168916.3.
DR RefSeq; NP_730648.1; NM_168917.3.
DR RefSeq; NP_730649.1; NM_168918.3.
DR RefSeq; NP_730650.1; NM_168919.3.
DR AlphaFoldDB; Q7K0L4; -.
DR SMR; Q7K0L4; -.
DR BioGRID; 65631; 19.
DR IntAct; Q7K0L4; 10.
DR STRING; 7227.FBpp0078015; -.
DR iPTMnet; Q7K0L4; -.
DR PaxDb; Q7K0L4; -.
DR PRIDE; Q7K0L4; -.
DR DNASU; 40386; -.
DR EnsemblMetazoa; FBtr0078359; FBpp0078015; FBgn0037094.
DR EnsemblMetazoa; FBtr0078361; FBpp0078017; FBgn0037094.
DR EnsemblMetazoa; FBtr0078362; FBpp0078018; FBgn0037094.
DR EnsemblMetazoa; FBtr0078363; FBpp0078019; FBgn0037094.
DR EnsemblMetazoa; FBtr0078364; FBpp0078020; FBgn0037094.
DR EnsemblMetazoa; FBtr0078365; FBpp0078021; FBgn0037094.
DR EnsemblMetazoa; FBtr0078366; FBpp0078022; FBgn0037094.
DR EnsemblMetazoa; FBtr0301197; FBpp0290415; FBgn0037094.
DR EnsemblMetazoa; FBtr0301198; FBpp0290416; FBgn0037094.
DR GeneID; 40386; -.
DR KEGG; dme:Dmel_CG7611; -.
DR FlyBase; FBgn0037094; CG7611.
DR VEuPathDB; VectorBase:FBgn0037094; -.
DR eggNOG; KOG0293; Eukaryota.
DR GeneTree; ENSGT00940000153634; -.
DR HOGENOM; CLU_000288_57_25_1; -.
DR InParanoid; Q7K0L4; -.
DR OMA; YCKFSPD; -.
DR OrthoDB; 349428at2759; -.
DR PhylomeDB; Q7K0L4; -.
DR BioGRID-ORCS; 40386; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40386; -.
DR PRO; PR:Q7K0L4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0037094; Expressed in adult midgut (Drosophila) and 22 other tissues.
DR ExpressionAtlas; Q7K0L4; baseline and differential.
DR Genevisible; Q7K0L4; DM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0034657; C:GID complex; IDA:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Mitochondrion; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..630
FT /note="WD repeat-containing protein 26 homolog"
FT /id="PRO_0000280739"
FT DOMAIN 96..128
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT DOMAIN 129..190
FT /note="CTLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT REPEAT 312..351
FT /note="WD 1"
FT REPEAT 359..400
FT /note="WD 2"
FT REPEAT 404..443
FT /note="WD 3"
FT REPEAT 445..482
FT /note="WD 4"
FT REPEAT 485..524
FT /note="WD 5"
FT REPEAT 529..569
FT /note="WD 6"
FT REPEAT 572..612
FT /note="WD 7"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 630 AA; 69617 MW; 1EB3D568E791AEBB CRC64;
MQSTSSTSSG SCSRPLEGST LNSGGSAENV ARDGGSGDDS VGIGDENPSG SSAATNGHDS
KHNGFIVNNN GSSSRIVDGE NNRENTSCSG VQLDKSNQEI IRLIGQYLHD VGLDKSVQTL
MLESGCYLEH PSATKFREHV LMGDWSKADS DLKDLEPLID NGKLATITEM KFILLEQKYL
EHLDDGNPLD ALHVLRSELT PLQHNITRVH QLSSYMMCST NQDLYQRAKW EGKGILSRAL
VMERLQTFMP PSVMMSPRRL RTLLQQAVEL QSQHCPCHDM AWETNLETVS LLTDHCCTTD
GFPMQTIQIL TDHCDEVWFC KFSPDGLKLA TGSKDSTVII WDVDPYKLTL KHRRVLDGQA
QLSVSFVSWS PDSKLILVGG TEDSHELYIW NVDDGKLVVK FSQSLEDSLA CGAFSRDGAR
FVCGGQKGQL YLCDLNGTIV DSWEGVRVNS IAFRADNKTI LAADNHYRIR GYNFDSPRSD
FDILREPHPI MTFSINSADR LALLNVSNQG LHLWDIEDKC LVRRFQGIRQ SNFAIHSCFG
GVNESFVASG SEDKVVYIWH IKREEPLAKL AGHTKTVNCV SWNPVYPSLL ASASDDATVR
IWGPKPNGSS ATTESDDCSS SSSSSSWNMT
