WDR27_HUMAN
ID WDR27_HUMAN Reviewed; 827 AA.
AC A2RRH5; A5PLM8; C9JGV0; Q5T066;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=WD repeat-containing protein 27;
GN Name=WDR27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), AND VARIANTS
RP PRO-133 AND HIS-437.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A2RRH5; P08243: ASNS; NbExp=3; IntAct=EBI-9476803, EBI-722989;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A2RRH5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2RRH5-2; Sequence=VSP_028510;
CC Name=3;
CC IsoId=A2RRH5-3; Sequence=VSP_028511, VSP_028512;
CC Name=4;
CC IsoId=A2RRH5-4; Sequence=VSP_040796, VSP_040797;
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DR EMBL; AL031315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL135910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL441927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040606; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC131633; AAI31634.1; -; mRNA.
DR EMBL; BC142982; AAI42983.1; -; mRNA.
DR CCDS; CCDS47520.2; -. [A2RRH5-4]
DR CCDS; CCDS56459.1; -. [A2RRH5-2]
DR RefSeq; NP_001189479.1; NM_001202550.1. [A2RRH5-2]
DR RefSeq; NP_872358.4; NM_182552.4. [A2RRH5-4]
DR AlphaFoldDB; A2RRH5; -.
DR BioGRID; 128986; 22.
DR IntAct; A2RRH5; 2.
DR STRING; 9606.ENSP00000416289; -.
DR iPTMnet; A2RRH5; -.
DR PhosphoSitePlus; A2RRH5; -.
DR BioMuta; WDR27; -.
DR MassIVE; A2RRH5; -.
DR PaxDb; A2RRH5; -.
DR PeptideAtlas; A2RRH5; -.
DR PRIDE; A2RRH5; -.
DR TopDownProteomics; A2RRH5-2; -. [A2RRH5-2]
DR Antibodypedia; 49469; 105 antibodies from 18 providers.
DR DNASU; 253769; -.
DR Ensembl; ENST00000423258.5; ENSP00000397869.1; ENSG00000184465.16. [A2RRH5-2]
DR Ensembl; ENST00000448612.6; ENSP00000416289.1; ENSG00000184465.16. [A2RRH5-4]
DR GeneID; 253769; -.
DR KEGG; hsa:253769; -.
DR MANE-Select; ENST00000448612.6; ENSP00000416289.1; NM_182552.5; NP_872358.4. [A2RRH5-4]
DR UCSC; uc003qwx.4; human. [A2RRH5-1]
DR CTD; 253769; -.
DR DisGeNET; 253769; -.
DR GeneCards; WDR27; -.
DR HGNC; HGNC:21248; WDR27.
DR HPA; ENSG00000184465; Low tissue specificity.
DR neXtProt; NX_A2RRH5; -.
DR OpenTargets; ENSG00000184465; -.
DR PharmGKB; PA134875091; -.
DR VEuPathDB; HostDB:ENSG00000184465; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00390000012017; -.
DR HOGENOM; CLU_018295_0_0_1; -.
DR InParanoid; A2RRH5; -.
DR OMA; EFCPWQT; -.
DR OrthoDB; 698548at2759; -.
DR PhylomeDB; A2RRH5; -.
DR TreeFam; TF351563; -.
DR PathwayCommons; A2RRH5; -.
DR SignaLink; A2RRH5; -.
DR BioGRID-ORCS; 253769; 5 hits in 1082 CRISPR screens.
DR ChiTaRS; WDR27; human.
DR GenomeRNAi; 253769; -.
DR Pharos; A2RRH5; Tdark.
DR PRO; PR:A2RRH5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; A2RRH5; protein.
DR Bgee; ENSG00000184465; Expressed in right uterine tube and 156 other tissues.
DR ExpressionAtlas; A2RRH5; baseline and differential.
DR Genevisible; A2RRH5; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR042411; WDR27.
DR PANTHER; PTHR44525; PTHR44525; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..827
FT /note="WD repeat-containing protein 27"
FT /id="PRO_0000306831"
FT REPEAT 3..57
FT /note="WD 1"
FT REPEAT 62..101
FT /note="WD 2"
FT REPEAT 112..151
FT /note="WD 3"
FT REPEAT 155..194
FT /note="WD 4"
FT REPEAT 201..237
FT /note="WD 5"
FT REPEAT 292..337
FT /note="WD 6"
FT REPEAT 344..387
FT /note="WD 7"
FT REPEAT 502..542
FT /note="WD 8"
FT REPEAT 546..584
FT /note="WD 9"
FT REPEAT 590..629
FT /note="WD 10"
FT REPEAT 646..687
FT /note="WD 11"
FT REPEAT 698..740
FT /note="WD 12"
FT REPEAT 746..784
FT /note="WD 13"
FT REPEAT 788..826
FT /note="WD 14"
FT VAR_SEQ 111..207
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028510"
FT VAR_SEQ 111..112
FT /note="GL -> GK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028511"
FT VAR_SEQ 113..827
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028512"
FT VAR_SEQ 152
FT /note="E -> EQRFSVTYIERPDVNNRHKVPPPTFLHTFSQ (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040796"
FT VAR_SEQ 812..827
FT /note="LATATLDGKLQLFLAE -> MESRSVAHAGVQWHDLGSLQPPPSRFKQFFCL
FT SLPSSWDYSLPQLPWMVNSSSF (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040797"
FT VARIANT 133
FT /note="L -> P (in dbSNP:rs4236176)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035317"
FT VARIANT 393
FT /note="V -> L (in dbSNP:rs35895089)"
FT /id="VAR_035318"
FT VARIANT 437
FT /note="R -> H (in dbSNP:rs3800544)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035319"
FT VARIANT 470
FT /note="P -> L (in dbSNP:rs34313252)"
FT /id="VAR_035320"
FT VARIANT 697
FT /note="A -> V (in dbSNP:rs9396946)"
FT /id="VAR_035321"
FT CONFLICT 153
FT /note="T -> A (in Ref. 2; BC040606)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="T -> S (in Ref. 2; AAI31634/AAI42983)"
FT /evidence="ECO:0000305"
FT CONFLICT A2RRH5-4:845
FT /note="R -> C (in Ref. 2; BC040606)"
FT /evidence="ECO:0000305"
FT CONFLICT A2RRH5-4:875
FT /note="L -> F (in Ref. 2; BC040606)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 827 AA; 90038 MW; 932404623943AC4C CRC64;
MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT ELCIWNTKDP
SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN LDECREKVLQ GLVPRGTVMG
SLLGKVLCLQ LSLDDHVVAV CAGNKIFMLD IETQAVRAEL QGHLGPVTAV EFCPWRAGTL
ISASEDRGFK VWDHCTGSLI YSSSVLSAYP LLSLFIDAES RQLVTGCADG QLWIFSLMDG
HHYRRVARVD LRKKTETFST RRVKSGLCSQ PEESQLPSTS ALGKGEQVEV TFPVLRLAPC
DLSLIPNSAC GCLSSENTRC VWIGSSVGLF VFNLANLEVE AALYYKDFQS LSILLAGSCA
LRNRTADQKV LCLLASLFGG KIAVLEINPA ALVRAQQCPS MGQSLSVPAS SCVLPTSPLY
LGIAKEKSTK AASEQRRAAR NVMKDQRLVF HSKVRSSGYA SAPHVTMFSP KTNIKSEGKG
SSRSRSSCAR EAYPVECAVP TKPGPQVAAA PTCTRVCCIQ YSGDGQWLAC GLANHLLLVF
DASLTGTPAV FSGHDGAVNA VCWSQDRRWL LSAARDGTLR MWSARGAELA LLLGKDMFSK
PIQSAQFYYI DAFILLSSGP EFQLLRYHID TCKDEIKRYK QKSKSKLICR LSTTGAVDMT
SLSAVNDFYS HIVLAAGRNR TVEVFDLNAG CSAAVIAEAH SRPVHQICQN KGSSFTTQQP
QAYNLFLTTA IGDGMRLWDL RTLRCERHFE GHPTRGYPCG IAFSPCGRFA ACGAEDRHAY
VYEMGSSTFS HRLAGHTDTV TGVAFNPSAP QLATATLDGK LQLFLAE
