WDR27_MOUSE
ID WDR27_MOUSE Reviewed; 780 AA.
AC Q8C5V5; Q8CA00;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=WD repeat-containing protein 27;
GN Name=Wdr27;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30513.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC36582.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK040117; BAC30513.1; ALT_INIT; mRNA.
DR EMBL; AK077050; BAC36582.1; ALT_FRAME; mRNA.
DR CCDS; CCDS37443.1; -.
DR RefSeq; NP_780382.2; NM_175173.3.
DR AlphaFoldDB; Q8C5V5; -.
DR STRING; 10090.ENSMUSP00000126736; -.
DR PhosphoSitePlus; Q8C5V5; -.
DR PaxDb; Q8C5V5; -.
DR PRIDE; Q8C5V5; -.
DR ProteomicsDB; 297641; -.
DR Ensembl; ENSMUST00000170386; ENSMUSP00000126736; ENSMUSG00000046991.
DR Ensembl; ENSMUST00000228330; ENSMUSP00000153717; ENSMUSG00000046991.
DR GeneID; 71682; -.
DR KEGG; mmu:71682; -.
DR UCSC; uc008anc.1; mouse.
DR CTD; 253769; -.
DR MGI; MGI:1918932; Wdr27.
DR VEuPathDB; HostDB:ENSMUSG00000046991; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00390000012017; -.
DR HOGENOM; CLU_018295_0_0_1; -.
DR InParanoid; Q8C5V5; -.
DR OrthoDB; 698548at2759; -.
DR PhylomeDB; Q8C5V5; -.
DR TreeFam; TF351563; -.
DR BioGRID-ORCS; 71682; 10 hits in 75 CRISPR screens.
DR ChiTaRS; Wdr27; mouse.
DR PRO; PR:Q8C5V5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8C5V5; protein.
DR Bgee; ENSMUSG00000046991; Expressed in spermatid and 62 other tissues.
DR ExpressionAtlas; Q8C5V5; baseline and differential.
DR Genevisible; Q8C5V5; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR042411; WDR27.
DR PANTHER; PTHR44525; PTHR44525; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..780
FT /note="WD repeat-containing protein 27"
FT /id="PRO_0000306832"
FT REPEAT 3..56
FT /note="WD 1"
FT REPEAT 61..100
FT /note="WD 2"
FT REPEAT 111..150
FT /note="WD 3"
FT REPEAT 154..193
FT /note="WD 4"
FT REPEAT 200..236
FT /note="WD 5"
FT REPEAT 291..335
FT /note="WD 6"
FT REPEAT 342..385
FT /note="WD 7"
FT REPEAT 500..540
FT /note="WD 8"
FT REPEAT 544..582
FT /note="WD 9"
FT REPEAT 588..639
FT /note="WD 10"
FT REPEAT 644..685
FT /note="WD 11"
FT REPEAT 691..738
FT /note="WD 12"
FT REPEAT 752..779
FT /note="WD 13"
SQ SEQUENCE 780 AA; 86582 MW; 4296DD757273741D CRC64;
METPPEMPST DGHTRAIVTE RYVVESKKSA AHVPLACSTQ HCAFPLDGSR LCVWSSKDPS
HQLLTLQGHH QLITAVVFGN QIDPLLLCSA SEDYIIMWNV AECREKTLKG LTPRGTILGS
LLQTVLCLRF SLDDRAIAVC AGNKISVMDV EKQSVLVELK GHQGSVTAVE FCPWQAHTLI
SVSEDRSFKV WDFCVGSLIY SSSILTAYPL LNLLINEENQ QLVTGSADGQ LWIFSLMEGH
HYHCVAHVDV RKKRETFTTR RMMAEQCSLP EDHQCRCRHE ADKRGEAEAT FPILSLAPCD
LCLPDSQRGA FASECTKCLW IGSSTALFIL NLASFELEAA LHFKEFQSLS VQVAGSCAMV
SEPMSAKAFC MLSSMFGSKI AVLEIDLAAL LSTQQYPRAG KVLSVLASSC VLPTSPLYFG
IIKEKFPKLA NTKQHAVKSV VEDRPLVFHT KVRSSGYTLA PHMAMFSPKT NIKHHNKRSS
KYKNNYKCKE CSLENFLPRN LSRQVAVAQK PVAVSCLQFS GDGQKLACGL GNHLSLVFNA
SLSGPPAAFS GHDGAVSTIC WSHDKRWLLS TGRDRTLRVW SVHRTELMLL LAPDAFPKPV
TSAQFYYMDT FILLSSGPEF CLLKYHIDLC RDDIRRYKPK SRYKPIFRLP MTSGADITSL
SAVNDFYSHI VLTAGRDRAV EVFDLNAGCS AAVLAEVHSR PVHRICQNKG SSFVAQHSLA
YNLFLTAAVG DGIRLWDLRN LRLMCMKWAP AAFCTVLQDT QIRLLKWPST QQLLSLSQPP
