WDR31_HUMAN
ID WDR31_HUMAN Reviewed; 367 AA.
AC Q8NA23; Q5W0T9; Q96EG8;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=WD repeat-containing protein 31;
GN Name=WDR31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NA23-2; P55212: CASP6; NbExp=3; IntAct=EBI-25835937, EBI-718729;
CC Q8NA23-2; P21964-2: COMT; NbExp=3; IntAct=EBI-25835937, EBI-10200977;
CC Q8NA23-2; O00291: HIP1; NbExp=3; IntAct=EBI-25835937, EBI-473886;
CC Q8NA23-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-25835937, EBI-21591415;
CC Q8NA23-2; P0CG47: UBB; NbExp=3; IntAct=EBI-25835937, EBI-413034;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NA23-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NA23-2; Sequence=VSP_010418;
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DR EMBL; AK093240; BAC04106.1; -; mRNA.
DR EMBL; AL137066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL449305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87368.1; -; Genomic_DNA.
DR EMBL; BC012352; AAH12352.1; -; mRNA.
DR CCDS; CCDS35110.1; -. [Q8NA23-1]
DR CCDS; CCDS6792.1; -. [Q8NA23-2]
DR RefSeq; NP_001012361.1; NM_001012361.3. [Q8NA23-1]
DR RefSeq; NP_660284.1; NM_145241.4. [Q8NA23-2]
DR AlphaFoldDB; Q8NA23; -.
DR SMR; Q8NA23; -.
DR BioGRID; 125405; 1.
DR IntAct; Q8NA23; 6.
DR STRING; 9606.ENSP00000363308; -.
DR iPTMnet; Q8NA23; -.
DR PhosphoSitePlus; Q8NA23; -.
DR BioMuta; WDR31; -.
DR DMDM; 47606186; -.
DR MassIVE; Q8NA23; -.
DR PaxDb; Q8NA23; -.
DR PeptideAtlas; Q8NA23; -.
DR PRIDE; Q8NA23; -.
DR ProteomicsDB; 72624; -. [Q8NA23-1]
DR ProteomicsDB; 72625; -. [Q8NA23-2]
DR Antibodypedia; 15294; 28 antibodies from 11 providers.
DR DNASU; 114987; -.
DR Ensembl; ENST00000341761.8; ENSP00000345027.3; ENSG00000148225.16. [Q8NA23-2]
DR Ensembl; ENST00000374193.9; ENSP00000363308.3; ENSG00000148225.16. [Q8NA23-1]
DR Ensembl; ENST00000374195.7; ENSP00000363310.4; ENSG00000148225.16. [Q8NA23-2]
DR GeneID; 114987; -.
DR KEGG; hsa:114987; -.
DR MANE-Select; ENST00000374193.9; ENSP00000363308.3; NM_001012361.4; NP_001012361.1.
DR UCSC; uc004bhc.4; human. [Q8NA23-1]
DR CTD; 114987; -.
DR DisGeNET; 114987; -.
DR GeneCards; WDR31; -.
DR HGNC; HGNC:21421; WDR31.
DR HPA; ENSG00000148225; Tissue enhanced (retina).
DR neXtProt; NX_Q8NA23; -.
DR OpenTargets; ENSG00000148225; -.
DR PharmGKB; PA134959062; -.
DR VEuPathDB; HostDB:ENSG00000148225; -.
DR eggNOG; KOG0279; Eukaryota.
DR GeneTree; ENSGT00910000144273; -.
DR HOGENOM; CLU_061931_0_0_1; -.
DR InParanoid; Q8NA23; -.
DR OMA; QYEPAHQ; -.
DR PhylomeDB; Q8NA23; -.
DR TreeFam; TF312936; -.
DR PathwayCommons; Q8NA23; -.
DR SignaLink; Q8NA23; -.
DR BioGRID-ORCS; 114987; 10 hits in 1072 CRISPR screens.
DR ChiTaRS; WDR31; human.
DR GenomeRNAi; 114987; -.
DR Pharos; Q8NA23; Tdark.
DR PRO; PR:Q8NA23; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NA23; protein.
DR Bgee; ENSG00000148225; Expressed in bronchial epithelial cell and 108 other tissues.
DR ExpressionAtlas; Q8NA23; baseline and differential.
DR Genevisible; Q8NA23; HS.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR040066; WDR31.
DR PANTHER; PTHR19869; PTHR19869; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..367
FT /note="WD repeat-containing protein 31"
FT /id="PRO_0000051380"
FT REPEAT 53..90
FT /note="WD 1"
FT REPEAT 94..132
FT /note="WD 2"
FT REPEAT 137..175
FT /note="WD 3"
FT REPEAT 179..217
FT /note="WD 4"
FT REPEAT 221..264
FT /note="WD 5"
FT REPEAT 269..311
FT /note="WD 6"
FT REPEAT 315..353
FT /note="WD 7"
FT VAR_SEQ 40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010418"
FT VARIANT 113
FT /note="P -> S (in dbSNP:rs10817479)"
FT /id="VAR_053426"
SQ SEQUENCE 367 AA; 40840 MW; 57B317C3164749CA CRC64;
MLLLRCQLKQ APPQKVSFRF CVVMGKQQSK LKHSTYKYGR PDEIIEERIQ TKAFQEYSPA
HMDTVSVVAA LNSDLCVSGG KDKTVVAYNW KTGNVVKRFK GHEHEITKVA CIPKSSQFFS
ASRDRMVMMW DLHGSSQPRQ QLCGHAMVVT GLAVSPDSSQ LCTGSRDNTL LLWDVVTGQS
VERASVSRNV VTHLCWVPRE PYILQTSEDK TLRLWDSRGL QVAHMFPAKQ HIQTYCEVSV
DGHKCISCSN GFGGEGCEAT LWDLRQTRNR ICEYKGHFQT VASCVFLPRA LALMPLIATS
SHDCKVKIWN QDTGACLFTL SLDGSGPLTS LAVGDAISLL CASFNRGIHL LRMDHSQGLE
LQEVAAF
