WDR31_MOUSE
ID WDR31_MOUSE Reviewed; 367 AA.
AC Q9JHB4; Q3URZ0; Q9D3N4;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=WD repeat-containing protein 31;
DE AltName: Full=Spermatid WD repeat-containing protein;
DE Short=spWD;
GN Name=Wdr31;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC STRAIN=CD-1; TISSUE=Testis;
RA Catalano R.D., Mendis A., Hicks H., Vlad M., Hillhouse E.W.;
RT "Cloning and characterization of a mouse testis cDNA encoding a novel WD-
RT repeat protein.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Pelan S.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9JHB4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JHB4-2; Sequence=VSP_010419;
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DR EMBL; AF274321; AAF82376.1; -; mRNA.
DR EMBL; AL732594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK017259; BAB30658.1; -; mRNA.
DR EMBL; AK141026; BAE24547.1; -; mRNA.
DR EMBL; BC037102; AAH37102.1; -; mRNA.
DR CCDS; CCDS18240.1; -. [Q9JHB4-1]
DR CCDS; CCDS71402.1; -. [Q9JHB4-2]
DR RefSeq; NP_001277450.1; NM_001290521.1. [Q9JHB4-1]
DR RefSeq; NP_001277451.1; NM_001290522.1. [Q9JHB4-2]
DR RefSeq; NP_076086.1; NM_023597.2. [Q9JHB4-1]
DR RefSeq; XP_006538317.1; XM_006538254.2. [Q9JHB4-1]
DR AlphaFoldDB; Q9JHB4; -.
DR SMR; Q9JHB4; -.
DR STRING; 10090.ENSMUSP00000030087; -.
DR PhosphoSitePlus; Q9JHB4; -.
DR PaxDb; Q9JHB4; -.
DR PRIDE; Q9JHB4; -.
DR ProteomicsDB; 297642; -. [Q9JHB4-1]
DR ProteomicsDB; 297643; -. [Q9JHB4-2]
DR Antibodypedia; 15294; 28 antibodies from 11 providers.
DR DNASU; 71354; -.
DR Ensembl; ENSMUST00000030087; ENSMUSP00000030087; ENSMUSG00000028391. [Q9JHB4-1]
DR Ensembl; ENSMUST00000107452; ENSMUSP00000103076; ENSMUSG00000028391. [Q9JHB4-2]
DR Ensembl; ENSMUST00000120095; ENSMUSP00000112719; ENSMUSG00000028391. [Q9JHB4-1]
DR GeneID; 71354; -.
DR KEGG; mmu:71354; -.
DR UCSC; uc008tet.2; mouse. [Q9JHB4-1]
DR UCSC; uc008teu.2; mouse. [Q9JHB4-2]
DR CTD; 114987; -.
DR MGI; MGI:1918604; Wdr31.
DR VEuPathDB; HostDB:ENSMUSG00000028391; -.
DR eggNOG; KOG0279; Eukaryota.
DR GeneTree; ENSGT00910000144273; -.
DR HOGENOM; CLU_061931_0_0_1; -.
DR InParanoid; Q9JHB4; -.
DR OMA; QYEPAHQ; -.
DR OrthoDB; 582058at2759; -.
DR PhylomeDB; Q9JHB4; -.
DR TreeFam; TF312936; -.
DR BioGRID-ORCS; 71354; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Wdr31; mouse.
DR PRO; PR:Q9JHB4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9JHB4; protein.
DR Bgee; ENSMUSG00000028391; Expressed in spermatid and 118 other tissues.
DR ExpressionAtlas; Q9JHB4; baseline and differential.
DR Genevisible; Q9JHB4; MM.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR040066; WDR31.
DR PANTHER; PTHR19869; PTHR19869; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..367
FT /note="WD repeat-containing protein 31"
FT /id="PRO_0000051381"
FT REPEAT 60..100
FT /note="WD 1"
FT REPEAT 101..140
FT /note="WD 2"
FT REPEAT 144..183
FT /note="WD 3"
FT REPEAT 186..225
FT /note="WD 4"
FT REPEAT 276..319
FT /note="WD 5"
FT VAR_SEQ 39
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010419"
SQ SEQUENCE 367 AA; 40530 MW; F83729A3BD7D9A24 CRC64;
MLLLDGQLKP ALPQKVFCRL WAVMGKLQSK LRHSTYLYSR PDGIIEERVQ TKAPQEYIPV
HVDTVSVIAT LNSDLCISGG KDKTAVAYNW KTGRMVKRFT GHEREITKIA CIPKANQFFS
ASRDKTVLMW DLQGSSHPRQ QLSGHAMVVT GLAVSPDSSQ LCTGSRDNSL LLWDVGTGQC
VERASVSRNL VTHLCWVPSE PYIVQTSEDK TIRLWDSRGL QMAHMFPTKQ HIQTHCEVSV
DGHTCISCSS GFGGEGCEAT LWDLRQTRDR MCEYKGHFQT VASCVFLPKS TALMPMIATS
AHDSKVKIWN QDTGACLSTL SLDGSGPLTS LAVGDISSLL CASFYRGVHL LRVDHSQGLE
LQEVAAF
